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Literature DB >> 8202486

Fast photoinduced electron transfer through DNA intercalation.

C J Murphy¹, M R Arkin, N D Ghatlia, S Bossmann, N J Turro, J K Barton.

Abstract

We report evidence for fast photoinduced electron transfer mediated by the DNA helix that requires metal complexes that are avid intercalators of DNA. Here the donor bis(phenanthroline)(dipyridophenazine)ruthenium(II) [Ru(phen)2dppz2+] and acceptor bis(9,10-phenanthrenequinone diimine)(phenanthroline)rhodium(III) [Rh(phi)2phen3+] intercalate into DNA with Kb > 10(6) M-1. Luminescence quenching experiments in the presence of two different lengths of DNA yield upward-curving Stern-Volmer plots and the loss of luminescence intensity far exceeds the change in emission lifetimes. In the presence of a nonintercalative electron acceptor, Ru(NH3)3+(6), Ru(phen)2dppz2+ luminescence is quenched much less efficiently compared to that found for the intercalative Rh(phi)2phen3+ quencher and follows linear Stern-Volmer kinetics; steady-state and time-resolved Stern-Volmer plots are comparable in scale. These experiments are consistent with a model involving fast long-range electron transfer between intercalators through the DNA helix.

Entities: Chemical Species

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Year: 1994 PMID： 8202486 PMCID： PMC43985 DOI： 10.1073/pnas.91.12.5315

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

17 in total

1. Delineation of structural domains in eukaryotic 5S rRNA with a rhodium probe.

Authors: C S Chow; K M Hartmann; S L Rawlings; P W Huber; J K Barton
Journal: Biochemistry Date: 1992-04-07 Impact factor: 3.162

2. Structural polymorphism in the major groove of a 5S RNA gene complements the zinc finger domains of transcription factor IIIA.

Authors: P W Huber; T Morii; H Y Mei; J K Barton
Journal: Proc Natl Acad Sci U S A Date: 1991-12-01 Impact factor: 11.205

3. Accelerated electron transfer between metal complexes mediated by DNA.

Authors: M D Purugganan; C V Kumar; N J Turro; J K Barton
Journal: Science Date: 1988-09-23 Impact factor: 47.728

Review 4. Action at a distance along a DNA.

Authors: J C Wang; G N Giaever
Journal: Science Date: 1988-04-15 Impact factor: 47.728

5. Luminescence of ruthenium(II) polypyridyls: evidence for intercalative binding to Z-DNA.

Authors: A E Friedman; C V Kumar; N J Turro; J K Barton
Journal: Nucleic Acids Res Date: 1991-05-25 Impact factor: 16.971

6. 1H NMR studies of tris(phenanthroline) metal complexes bound to oligonucleotides: characterization of binding modes.

Authors: J P Rehmann; J K Barton
Journal: Biochemistry Date: 1990-02-20 Impact factor: 3.162

7. Photoinduced electron transfer quenching of excited Ru(II) polypyridyls bound to DNA: the role of the nucleic acid double helix.

Authors: G Orellana; A Kirsch-De Mesmaeker; J K Barton; N J Turro
Journal: Photochem Photobiol Date: 1991-10 Impact factor: 3.421

8. The interactions of ruthenium hexaammine with Z-DNA: crystal structure of a Ru(NH3)6+3 salt of d(CGCGCG) at 1.2 A resolution.

Authors: P S Ho; C A Frederick; D Saal; A H Wang; A Rich
Journal: J Biomol Struct Dyn Date: 1987-02

9. Characterization of dipyridophenazine complexes of ruthenium(II): the light switch effect as a function of nucleic acid sequence and conformation.

Authors: Y Jenkins; A E Friedman; N J Turro; J K Barton
Journal: Biochemistry Date: 1992-11-10 Impact factor: 3.162

10. Recognition of tertiary structure in tRNAs by Rh(phen)2phi3+, a new reagent for RNA structure-function mapping.

Authors: C S Chow; L S Behlen; O C Uhlenbeck; J K Barton
Journal: Biochemistry Date: 1992-02-04 Impact factor: 3.162

11 in total

Review 1. Fluorescence lifetime measurements and biological imaging.

Authors: Mikhail Y Berezin; Samuel Achilefu
Journal: Chem Rev Date: 2010-05-12 Impact factor: 60.622

2. Charge transfer and transport in DNA.

Authors: J Jortner; M Bixon; T Langenbacher; M E Michel-Beyerle
Journal: Proc Natl Acad Sci U S A Date: 1998-10-27 Impact factor: 11.205

3. Charge photoinjection in intercalated and covalently bound [Re(CO)3(dppz)(py)]+-DNA constructs monitored by time-resolved visible and infrared spectroscopy.

Authors: Eric D Olmon; Pamela A Sontz; Ana María Blanco-Rodríguez; Michael Towrie; Ian P Clark; Antonín Vlček; Jacqueline K Barton
Journal: J Am Chem Soc Date: 2011-08-09 Impact factor: 15.419

Review 4. Mechanisms for DNA charge transport.

Authors: Joseph C Genereux; Jacqueline K Barton
Journal: Chem Rev Date: 2010-03-10 Impact factor: 60.622