Literature DB >> 8202465

Thermodynamics of ubiquitin unfolding.

P L Wintrode1, G I Makhatadze, P L Privalov.   

Abstract

The energetics of ubiquitin unfolding have been studied using differential scanning microcalorimetry. For the first time it has been shown directly that the enthalpy of protein unfolding is a nonlinear function of temperature. Thermodynamic parameters of ubiquitin unfolding were correlated with the structure of the protein. The enthalpy of hydrogen bonding in ubiquitin was calculated and compared to that obtained for other proteins. It appears that the energy of hydrogen bonding correlates with the average length of the hydrogen bond in a given protein structure.

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Year:  1994        PMID： 8202465     DOI： 10.1002/prot.340180305

Source DB:  PubMed          Journal:  Proteins        ISSN： 0887-3585


  45 in total

1.  Role of hydration water in protein unfolding.

Authors:  G W Robinson; C H Cho
Journal:  Biophys J       Date:  1999-12       Impact factor: 4.033

2.  Contribution of proton linkage to the thermodynamic stability of the major cold-shock protein of Escherichia coli CspA.

Authors:  S A Petrosian; G I Makhatadze
Journal:  Protein Sci       Date:  2000-02       Impact factor: 6.725

3.  A systematic study of the vibrational free energies of polypeptides in folded and random states.

Authors:  B Ma; C J Tsai; R Nussinov
Journal:  Biophys J       Date:  2000-11       Impact factor: 4.033

4.  On the thermal unfolding character of globular proteins.

Authors:  R Muthusamy; M M Gromiha; P K Ponnuswamy
Journal:  J Protein Chem       Date:  2000-01

5.  Are proteins well-packed?

Authors:  J Liang; K A Dill
Journal:  Biophys J       Date:  2001-08       Impact factor: 4.033

6.  Heat capacity changes upon burial of polar and nonpolar groups in proteins.

Authors:  V V Loladze; D N Ermolenko; G I Makhatadze
Journal:  Protein Sci       Date:  2001-07       Impact factor: 6.725

7.  Electrothermal supercharging of proteins in native electrospray ionization.

Authors:  Harry J Sterling; Catherine A Cassou; Anna C Susa; Evan R Williams
Journal:  Anal Chem       Date:  2012-03-19       Impact factor: 6.986

8.  Allosteric switching by mutually exclusive folding of protein domains.

Authors:  Tracy L Radley; Anna I Markowska; Blaine T Bettinger; Jeung-Hoi Ha; Stewart N Loh
Journal:  J Mol Biol       Date:  2003-09-19       Impact factor: 5.469

9.  Elucidating protein thermodynamics from the three-dimensional structure of the native state using network rigidity.

Authors:  Donald J Jacobs; Sargis Dallakyan
Journal:  Biophys J       Date:  2004-11-12       Impact factor: 4.033

10.  Thermal coefficients of the methyl groups within ubiquitin.

Authors:  T Michael Sabo; Davood Bakhtiari; Korvin F A Walter; Robert L McFeeters; Karin Giller; Stefan Becker; Christian Griesinger; Donghan Lee
Journal:  Protein Sci       Date:  2012-03-02       Impact factor: 6.725
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