The role of parathyroid hormone and vitamin D in acid excretion and extrarenal buffer mobilization.

Parathyroid hormone (PTH) and vitamin D are involved in the maintenance of acid-base homeostasis by enhancing urinary acid excretion and mobilizing extrarenal buffer present in bone. Acidosis may alter hormonal effect and metabolism. Conclusions reached from experimental and clinical states of hormonal deficiency and excess must take into account differences due to species and methodologies. This paper critically reviews the role of PTH and vitamin D on acid-base metabolism.