Literature DB >> 820087

Some phenolic metabolites of 2, 4-diaminotoluene in the rabbit, rat and guinea-pig.

R H Waring, A E Pheasant.   

Abstract

1. After administration of 2,4-diaminotoluene to rabbits, rats and guinea-pigs, phenolic metabolites are excreted, the major component being 5-hydroxy-2,4-diaminotoluene in all species investigated. Acetylated aminophenols and glucuronide conjugates were also found. 2. Rabbits, which produced the largest amounts of free amino-phenols, also had the highest levels of methaemoglobin in vivo.

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Year:  1976        PMID： 820087     DOI： 10.3109/00498257609151635

Source DB:  PubMed          Journal:  Xenobiotica        ISSN： 0049-8254            Impact factor:   1.908


  4 in total

1.  Comparing the performance and coverage of selected in silico (liver) metabolism tools relative to reported studies in the literature to inform analogue selection in read-across: A case study.

Authors:  Matthew Boyce; Brian Meyer; Chris Grulke; Lucina Lizarraga; Grace Patlewicz
Journal:  Comput Toxicol       Date:  2022-02-01

2.  Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate.

Authors:  G Skarping; T Brorson; C Sangö
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015

3.  Methemoglobin formation and binding to blood constituents as indicators for the formation, availability and reactivity of activated metabolites derived from trans-4-aminostilbene and related aromatic amines.

Authors:  E Wieland; H G Neumann
Journal:  Arch Toxicol       Date:  1978-02-21       Impact factor: 5.153

4.  A physiologically based pharmacokinetic model for 2,4-toluenediamine leached from polyurethane foam-covered breast implants.

Authors:  H M Luu; J C Hutter; H F Bushar
Journal:  Environ Health Perspect       Date:  1998-07       Impact factor: 9.031
  4 in total

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