Literature DB >> 8199694

Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.

F Kurokawa1.   

Abstract

To investigate the specific phenotype of hyperplastic nodules (HPN) in rat liver, we produced a monoclonal antibody (HAM-6). HAM-6 was a member of the mouse IgG1 class and was specific for hyperplastic nodules, as shown by cellular radioimmunoassay and immunohistochemical studies. The antigen recognized by HAM-6 was located in the rat HPN cell membrane. HAM-6 was also slightly reactive to rat hepatocellular carcinoma, but not to normal or fetal rat liver, other normal rat organs, human hepatocellular carcinoma, or human liver cirrhosis. That is, the antigen recognized by HAM-6 appeared to be differentiated and to occur during chemical carcinogenesis. HAM-6 may be a useful marker for the investigation of premalignant states in chemical carcinogenesis.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8199694     DOI： 10.1007/bf01229071

Source DB:  PubMed          Journal:  J Gastroenterol        ISSN： 0944-1174            Impact factor:   7.527


  9 in total

1.  Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene.

Authors:  E FARBER
Journal:  Cancer Res       Date:  1956-02       Impact factor: 12.701

2.  A new common marker for premalignant and malignant hepatocytes induced in the rat by chemical carcinogens.

Authors:  K Okita; L H Kligman; E Farber
Journal:  J Natl Cancer Inst       Date:  1975-01       Impact factor: 13.506

3.  Identification of epoxide hydrase as the preneoplastic antigen in rat liver hyperplastic nodules.

Authors:  W Levin; A Y Lu; P E Thomas; D Ryan; D E Kizer; M J Griffin
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

4.  Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.

Authors:  S Epstein; N Ito; L Merkow; E Farber
Journal:  Cancer Res       Date:  1967-09       Impact factor: 12.701

5.  Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis.

Authors:  K Satoh; A Kitahara; Y Soma; Y Inaba; I Hatayama; K Sato
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

6.  Monoclonal antibodies to rat liver cell membrane glycoproteins.

Authors:  T Fukumoto; H Kimura; M Naito; M Miyamoto; A Yamashita; H Sugiyama
Journal:  Mol Immunol       Date:  1984-04       Impact factor: 4.407

7.  The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.

Authors:  R C Graham; M J Karnovsky
Journal:  J Histochem Cytochem       Date:  1966-04       Impact factor: 2.479

8.  Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.

Authors:  D B Solt; A Medline; E Farber
Journal:  Am J Pathol       Date:  1977-09       Impact factor: 4.307

9.  An antigen specific to hyperplastic liver nodules defined with monoclonal antibody: a new marker for preneoplastic cells in rat chemical hepatocarcinogenesis.

Authors:  K Okita; T Esaki; F Kurokawa; T Takemoto; Y Fujikura; T Fukumoto
Journal:  Tumour Biol       Date:  1988
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.