T Sorahan1, A M Faux, M A Cooke. 1. Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, UK.
Abstract
OBJECTIVE: The aim was to describe cause specific mortality among steel foundry workers and to determine if any part of the experience may be due to occupation. DESIGN: Historical prospective cohort study. SETTING: Nine steel foundries in England and one in Scotland. SUBJECTS: 10,438 male production employees first employed in the period 1946-65 and with a minimum period of employment of one year. MAIN OUTCOME MEASURES: Observed and expected numbers of deaths for the period 1946-90. RESULTS: Compared with the general population of England and Wales, standardised mortality ratios (SMRs) for all causes and all neoplasms were 115 (observed deaths (Obs) 3976) and 119 (Obs 1129) respectively. Statistically significant excesses were found for cancer of the stomach (Obs 124, expected deaths (Exp) 92.5, SMR 134, 95% confidence interval (95% CI) 111-160) and cancer of the lung (Obs 551, Exp 378.3, SMR 146, 95% CI 134-158). A raised SMR (153) was also found for non-malignant diseases of the respiratory system. Classifications of jobs attracting either higher dust or higher fume exposures did not usefully predict these increased SMRs. Poisson regression was used to investigate risks of mortality from all cancers, cancer of the stomach, cancer of the lung, and non-malignant diseases of the respiratory system associated with duration of employment in the foundry area, the fettling shop, the foundry area/fettling shop, and the industry in general. Monotonic dose-response relations were not found, although there were positive trends for lung cancer and employment in the foundry area/fettling shop (1.0, 1.21, 1.44, 1.26) and for diseases of the respiratory system and employment in the fettling shop (1.0, 1.37, 1.18, 1.35). CONCLUSIONS: Confident interpretation of the causes of the raised SMRs was not possible. There was limited evidence of an occupational role in the excesses of lung cancer and diseases of the respiratory system. Smoking history was shown, in an indirect way, to be an unlikely explanation.
OBJECTIVE: The aim was to describe cause specific mortality among steel foundry workers and to determine if any part of the experience may be due to occupation. DESIGN: Historical prospective cohort study. SETTING: Nine steel foundries in England and one in Scotland. SUBJECTS: 10,438 male production employees first employed in the period 1946-65 and with a minimum period of employment of one year. MAIN OUTCOME MEASURES: Observed and expected numbers of deaths for the period 1946-90. RESULTS: Compared with the general population of England and Wales, standardised mortality ratios (SMRs) for all causes and all neoplasms were 115 (observed deaths (Obs) 3976) and 119 (Obs 1129) respectively. Statistically significant excesses were found for cancer of the stomach (Obs 124, expected deaths (Exp) 92.5, SMR 134, 95% confidence interval (95% CI) 111-160) and cancer of the lung (Obs 551, Exp 378.3, SMR 146, 95% CI 134-158). A raised SMR (153) was also found for non-malignant diseases of the respiratory system. Classifications of jobs attracting either higher dust or higher fume exposures did not usefully predict these increased SMRs. Poisson regression was used to investigate risks of mortality from all cancers, cancer of the stomach, cancer of the lung, and non-malignant diseases of the respiratory system associated with duration of employment in the foundry area, the fettling shop, the foundry area/fettling shop, and the industry in general. Monotonic dose-response relations were not found, although there were positive trends for lung cancer and employment in the foundry area/fettling shop (1.0, 1.21, 1.44, 1.26) and for diseases of the respiratory system and employment in the fettling shop (1.0, 1.37, 1.18, 1.35). CONCLUSIONS: Confident interpretation of the causes of the raised SMRs was not possible. There was limited evidence of an occupational role in the excesses of lung cancer and diseases of the respiratory system. Smoking history was shown, in an indirect way, to be an unlikely explanation.
Authors: Lifang Hou; Zhong-Zheng Zhu; Xiao Zhang; Francesco Nordio; Matteo Bonzini; Joel Schwartz; Mirjam Hoxha; Laura Dioni; Barbara Marinelli; Valeria Pegoraro; Pietro Apostoli; Pier Alberto Bertazzi; Andrea Baccarelli Journal: Environ Health Date: 2010-08-09 Impact factor: 5.984
Authors: Letizia Tarantini; Matteo Bonzini; Pietro Apostoli; Valeria Pegoraro; Valentina Bollati; Barbara Marinelli; Laura Cantone; Giovanna Rizzo; Lifang Hou; Joel Schwartz; Pier Alberto Bertazzi; Andrea Baccarelli Journal: Environ Health Perspect Date: 2008-09-26 Impact factor: 9.031