Literature DB >> 8198968

Tumorigenicity of a combination of psoriasis therapies.

D H Phillips1, A J Alldrick.   

Abstract

Coal tar, a tumour initiator, and dithranol, a tumour promoter, are used in the treatment of psoriasis. Topical treatment of mice with pharmaceutical formulations of these two agents, at therapeutic doses, induced skin papillomas in a classical two-stage carcinogenesis protocol, while treatment with either agent alone did not. This finding has implications for the use of both agents in combination in the treatment of psoriasis.

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Year:  1994        PMID： 8198968      PMCID： PMC1969454          DOI： 10.1038/bjc.1994.205

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  9 in total

Review 1.  Side-effects of psoralen photochemotherapy (PUVA).

Authors:  K Wolff
Journal:  Br J Dermatol       Date:  1990-06       Impact factor: 9.302

2.  Aromatic DNA adducts in human bone marrow and peripheral blood leukocytes.

Authors:  D H Phillips; A Hewer; P L Grover
Journal:  Carcinogenesis       Date:  1986-12       Impact factor: 4.944

3.  Treatment of psoriasis with a combination of dithranol and coal tar.

Authors:  E Young; H van Weelden
Journal:  Br J Dermatol       Date:  1987-02       Impact factor: 9.302

Review 4.  International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC publication no. 6: do treatments available for psoriasis patients carry a genetic or carcinogenic risk?

Authors: 
Journal:  Mutat Res       Date:  1981-05       Impact factor: 2.433

5.  Skin cancer in patients with psoriasis treated with coal tar. A 25-year follow-up study.

Authors:  M R Pittelkow; H O Perry; S A Muller; W Z Maughan; P C O'Brien
Journal:  Arch Dermatol       Date:  1981-08

6.  Formation of DNA adducts in the skin of psoriasis patients, in human skin in organ culture, and in mouse skin and lung following topical application of coal-tar and juniper tar.

Authors:  B Schoket; I Horkay; A Kósa; L Páldeák; A Hewer; P L Grover; D H Phillips
Journal:  J Invest Dermatol       Date:  1990-02       Impact factor: 8.551

7.  Skin carcinoma in patients with psoriasis treated with topical tar and artificial ultraviolet radiation.

Authors:  R S Stern; S Zierler; J A Parrish
Journal:  Lancet       Date:  1980-04-05       Impact factor: 79.321

8.  Tumor-producing and skin-irritating activity of dithranol (anthralin) and its 10-acyl analogues in SENCAR mice.

Authors:  M Viluksela; E Puotunen; A J Newman; P T Männistö
Journal:  Carcinogenesis       Date:  1986-10       Impact factor: 4.944

9.  Covalent binding of components of coal-tar, creosote and bitumen to the DNA of the skin and lungs of mice following topical application.

Authors:  B Schoket; A Hewer; P L Grover; D H Phillips
Journal:  Carcinogenesis       Date:  1988-07       Impact factor: 4.944
  9 in total

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