OBJECTIVE: To determine age-related changes in neurologic function in the general population. DESIGN: To administer a neurologic examination to participants in such a way that it is possible to calculate the proportion of elderly persons in the population with each abnormal finding and the proportion of persons with each finding but without evidence of the medical and neurologic diseases likely to produce neurologic abnormalities (eg, stroke and diabetes). SETTING: Individuals were selected from a community-dwelling population. PARTICIPANTS: A stratified random sample of 467 persons aged 65 years and older were evaluated. RESULTS: Many neurologic abnormalities are increasingly common with advancing age and are present in a substantial portion of the elderly population. The prevalence of abnormal neurologic findings not attributable to disease, however, is substantially lower, typically one half to one third the total prevalence. Moreover, the increase with age in the prevalence of abnormal neurologic findings not attributable to major disease varies substantially among the different measures. CONCLUSIONS: Primitive reflexes and measures of gait show statistically significant increases with age in multiple measurement domains, suggesting a selective age-related vulnerability.
OBJECTIVE: To determine age-related changes in neurologic function in the general population. DESIGN: To administer a neurologic examination to participants in such a way that it is possible to calculate the proportion of elderly persons in the population with each abnormal finding and the proportion of persons with each finding but without evidence of the medical and neurologic diseases likely to produce neurologic abnormalities (eg, stroke and diabetes). SETTING: Individuals were selected from a community-dwelling population. PARTICIPANTS: A stratified random sample of 467 persons aged 65 years and older were evaluated. RESULTS: Many neurologic abnormalities are increasingly common with advancing age and are present in a substantial portion of the elderly population. The prevalence of abnormal neurologic findings not attributable to disease, however, is substantially lower, typically one half to one third the total prevalence. Moreover, the increase with age in the prevalence of abnormal neurologic findings not attributable to major disease varies substantially among the different measures. CONCLUSIONS: Primitive reflexes and measures of gait show statistically significant increases with age in multiple measurement domains, suggesting a selective age-related vulnerability.
Authors: Olivier Beauchet; Cédric Annweiler; Michele L Callisaya; Anne-Marie De Cock; Jorunn L Helbostad; Reto W Kressig; Velandai Srikanth; Jean-Paul Steinmetz; Helena M Blumen; Joe Verghese; Gilles Allali Journal: J Am Med Dir Assoc Date: 2016-02-04 Impact factor: 4.669
Authors: Olivier Piguet; Jane Cramsie; Hayley P Bennett; Jillian J Kril; Tanya C Lye; Alastair J Corbett; Michael Hayes; Helen Creasey; G Anthony Broe Journal: Eur Arch Psychiatry Clin Neurosci Date: 2006-08-17 Impact factor: 5.270
Authors: Alexander F J E Vrancken; Sandra Kalmijn; Frans Brugman; Gabriël J E Rinkel; Nicolette C Notermans Journal: J Neurol Date: 2005-11-23 Impact factor: 4.849
Authors: Nicola Moscufo; Charles R G Guttmann; Dominik Meier; Istvan Csapo; Peter G Hildenbrand; Brian C Healy; Julia A Schmidt; Leslie Wolfson Journal: Neurobiol Aging Date: 2009-05-09 Impact factor: 4.673
Authors: J M Starr; S A Leaper; A D Murray; H A Lemmon; R T Staff; I J Deary; L J Whalley Journal: J Neurol Neurosurg Psychiatry Date: 2003-01 Impact factor: 10.154