Literature DB >> 8195820

Changes in peripheral blood lymphocyte subset frequencies in myasthenia gravis patients are related to immunosuppression.

F Crosti1, M Armanini, P Confalonieri, C Antozzi, R Mantegazza.   

Abstract

Surface antigens on peripheral blood lymphocytes from myasthenia gravis patients were investigated. The expression of DR+ and CD8+/DR+ T lymphocytes was increased and the expression of CD4+ T cells reduced. Neither thymectomy, clinical condition nor anti-acetylcholine receptor antibody titre correlated with any of the changes in peripheral blood lymphocyte subsets observed. However, immunosuppressive therapy correlated with the significant reduction in CD4+ and CD2+/CD4+ T cells in these patients.

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Year:  1994        PMID： 8195820     DOI： 10.1007/BF00863771

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  21 in total

Review 1.  Do CD2 and CD3-TCR T-cell activation pathways function independently?

Authors:  D Kabelitz
Journal:  Immunol Today       Date:  1990-02

2.  Phenotypic and functional characterization of T cells from patients with myasthenia gravis.

Authors:  F Mokhtarian; M Pino; W Ofosu-Appiah; D Grob
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

3.  In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes.

Authors:  S Brocke; C Brautbar; L Steinman; O Abramsky; J Rothbard; D Neumann; S Fuchs; E Mozes
Journal:  J Clin Invest       Date:  1988-12       Impact factor: 14.808

Review 4.  Myasthenia gravis.

Authors:  J Lindstrom; D Shelton; Y Fujii
Journal:  Adv Immunol       Date:  1988       Impact factor: 3.543

5.  Monoclonal antibody analysis of blood T-cell subsets in myasthenia gravis.

Authors:  P R Skolnik; R P Lisak; B Zweiman
Journal:  Ann Neurol       Date:  1982-02       Impact factor: 10.422

6.  Lymphocyte subsets of the peripheral blood in myasthenia gravis determined by two-color flow cytometry.

Authors:  H Shimizu; Y Ichikawa; M Yoshida; K Takahashi; S Arimori
Journal:  Autoimmunity       Date:  1990       Impact factor: 2.815

7.  Thymectomy and azathioprine have no effect on the phenotype of CD4 T lymphocyte subsets in myasthenia gravis.

Authors:  A Melms; G Malcherek; U Gern; N Sommer; R Weissert; H Wiethölter; H J Bühring
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-01       Impact factor: 10.154

8.  A juxta-membrane epitope on the human acetylcholine receptor recognized by T cells in myasthenia gravis.

Authors:  G C Harcourt; N Sommer; J Rothbard; H N Willcox; J Newsom-Davis
Journal:  J Clin Invest       Date:  1988-10       Impact factor: 14.808

9.  Immune regulation in myasthenia gravis: evidence for an increased suppressor T-cell population.

Authors:  A E Miller; J Hudson; R S Tindall
Journal:  Ann Neurol       Date:  1982-10       Impact factor: 10.422

10.  Evaluation of T cell subsets in myasthenia gravis using anti-T cell monoclonal antibodies.

Authors:  S Berrih; C Gaud; M A Bach; H Le Brigand; J P Binet; J F Bach
Journal:  Clin Exp Immunol       Date:  1981-07       Impact factor: 4.330
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