| Literature DB >> 8195445 |
R A Seymour1, J S Ellis, J M Thomason, S Monkman, J R Idle.
Abstract
Amlodipine is a calcium channel blocker used in the management of angina and hypertension. We report 3 cases of gingival overgrowth in adult dentate patients associated with chronic usage of this drug. Gingival changes occurred within 3 months of dosage and appeared to be compounded by the patient's existing periodontal condition. In all 3 patients, there was sequestration of amlodipine in their crevicular fluid. The significance of this finding in relation to the pathogenesis of this unwanted effect remains to be elucidated.Entities:
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Year: 1994 PMID： 8195445 DOI： 10.1111/j.1600-051x.1994.tb00318.x
Source DB: PubMed Journal: J Clin Periodontol ISSN： 0303-6979 Impact factor: 8.728