Literature DB >> 8195042

Fungal metabolites. Part 14. Novel potent immunosuppressants, mycestericins, produced by Mycelia sterilia.

S Sasaki1, R Hashimoto, M Kiuchi, K Inoue, T Ikumoto, R Hirose, K Chiba, Y Hoshino, T Okumoto, T Fujita.   

Abstract

Mycestericins A, B, C, D and E were isolated from the culture broth of Mycelia sterilia ATCC 20349 along with thermozymocidin (= myriocin). Their structures were elucidated on the basis of spectroscopic studies and chemical evidence. The acetate of mycestericin C was identical with the acetate of 6,7-dihydromyriocin. Mycestericins suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction, with a potency similar to that of myriocin.

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Year:  1994        PMID： 8195042     DOI： 10.7164/antibiotics.47.420

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

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Authors:  Alexander Kornienko; Antonio Evidente; Maurizio Vurro; Véronique Mathieu; Alessio Cimmino; Marco Evidente; Willem A L van Otterlo; Ramesh Dasari; Florence Lefranc; Robert Kiss
Journal:  Med Res Rev       Date:  2015-04-08       Impact factor: 12.944

Review 2.  Discovery of fingolimod based on the chemical modification of a natural product from the fungus, Isaria sinclairii.

Authors:  Kenji Chiba
Journal:  J Antibiot (Tokyo)       Date:  2020-07-17       Impact factor: 2.649

3.  Endophytic fungal compounds active against Cryptococcus neoformans and C. gattii.

Authors:  Cristiane B Pereira; Djalma M de Oliveira; Alice Fs Hughes; Markus Kohlhoff; Mariana LA Vieira; Aline B Martins Vaz; Mariana C Ferreira; Camila R Carvalho; Luiz H Rosa; Carlos A Rosa; Tânia Ma Alves; Carlos L Zani; Susana Johann; Betania B Cota
Journal:  J Antibiot (Tokyo)       Date:  2015-02-25       Impact factor: 2.649

4.  Catalytic Asymmetric Direct Aldol Reaction of α-Alkyl Azlactones and Aliphatic Aldehydes.

Authors:  Yang Zheng; Li Deng
Journal:  Chem Sci       Date:  2015-08-04       Impact factor: 9.825

Review 5.  Structural simplification: an efficient strategy in lead optimization.

Authors:  Shengzheng Wang; Guoqiang Dong; Chunquan Sheng
Journal:  Acta Pharm Sin B       Date:  2019-06-06       Impact factor: 11.413

6.  FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology.

Authors:  Kunitomo Adachi; Kenji Chiba
Journal:  Perspect Medicin Chem       Date:  2007-09-06
  6 in total

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