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Literature DB >> 819463

Effects of meningococcal and Escherichia coli capsular polysaccharides on human and dog platelet aggregation in vitro.

Abstract

Highly purified capsular polysaccharides from groups A, B, and C meningococci and from two strains of Escherichia coli did not aggregate human or dog platelets in vitro. Nor was there any detectable effect on platelet aggregation induced by adenosine diphosphate (ADP), epinephrine, or collagen. The results do not support the hypothesis that capsular polysaccharides are involved in the pathogenesis of thrombocytopenia often seen in severe infections with these bacteria.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1976 PMID： 819463 PMCID： PMC476083 DOI： 10.1136/jcp.29.5.438

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

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References

13 in total

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Authors: R P GILBERT
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Authors: M W Rytel; T H Dee; J E Ferstenfeld; G T Hensley
Journal: Am J Med Date: 1974-12 Impact factor: 4.965

10. Human immunity to the meningococcus. 3. Preparation and immunochemical properties of the group A, group B, and group C meningococcal polysaccharides.

Authors: E C Gotschlich; T Y Liu; M S Artenstein
Journal: J Exp Med Date: 1969-06-01 Impact factor: 14.307

Effects of meningococcal and Escherichia coli capsular polysaccharides on human and dog platelet aggregation in vitro.

Review 1. THE SHWARTZMAN REACTION: PATHOGENETIC MECHANISMS AND CLINICAL MANIFESTATIONS.

2. THE AGGREGATION OF HUMAN PLATELETS BY BACTERIAL ENDOTOXIN.

3. Aggregation of blood platelets by adenosine diphosphate and its reversal.

4. Mechanisms of the hemodynamic effects of endotoxin.

5. Possible pathogenetic role of capsular antigens in fulminant pneumococcal disease with disseminated intravascular coagulation (DIC).

6. Group-specific polysaccharide antigen and humoral antibody response in disease due to Neisseria meningitidis.

Review 7. Factors influencing platelet function: adhesion, release, and aggregation.

8. Endotoxin and endotoxemia.

9. Effects of a variety of endotoxins on human and rabbit platelet function.

10. Human immunity to the meningococcus. 3. Preparation and immunochemical properties of the group A, group B, and group C meningococcal polysaccharides.