Literature DB >> 8194597

Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines.

W T Couldwell1, D R Hinton, S He, T C Chen, I Sebat, M H Weiss, R E Law.   

Abstract

Previous work has demonstrated the importance of the protein kinase C (PKC) system in regulating glioma growth, and has led to clinical trials utilizing PKC inhibitors as adjuncts in the therapy of patients harboring malignant gliomas. This study was performed to explore the possibility that inhibition of PKC in gliomas was triggering an apoptosis signal. Glioma cell lines were treated with PKC inhibitors staurosporine (10 nM), and tamoxifen (10 microM). DNA from cells treated with each of these drugs exhibited a 'ladder' pattern of oligonucleosome-sized fragments characteristic of apoptosis, thus suggesting that in glioma cells, these drugs may be cytocidal in action.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 8194597     DOI： 10.1016/0014-5793(94)00415-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  54 in total

1.  Sensitivity of human glioma U-373MG cells to radiation and the protein kinase C inhibitor, calphostin C.

Authors:  M Acevedo-Duncan; J Pearlman; B Zachariah
Journal:  Cell Prolif       Date:  2001-02       Impact factor: 6.831

2.  Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion.

Authors:  M Bredel; I F Pollack; J M Freund; J Rusnak; J S Lazo
Journal:  J Neurooncol       Date:  1999-01       Impact factor: 4.130

3.  Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration.

Authors:  Chrysanthi Samara; Christopher B Rohde; Cody L Gilleland; Stephanie Norton; Stephen J Haggarty; Mehmet Fatih Yanik
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-11       Impact factor: 11.205

4.  Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus.

Authors:  Kathleen E McGrath; Paul D Kingsley; Anne D Koniski; Rebecca L Porter; Timothy P Bushnell; James Palis
Journal:  Blood       Date:  2007-11-21       Impact factor: 22.113

5.  The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor.

Authors:  Tamara Frankenberg; Tamir Miloh; Frank Y Chen; Meena Ananthanarayanan; An-Qiang Sun; Natarajan Balasubramaniyan; Irwin Arias; Kenneth D R Setchell; Frederick J Suchy; Benjamin L Shneider
Journal:  Hepatology       Date:  2008-12       Impact factor: 17.425

6.  Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells.

Authors:  Amna Hashim; Grace Mulcahy; Billy Bourke; Marguerite Clyne
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

7.  Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis: the role of the low-affinity NGF receptor.

Authors:  M H Cortazzo; E S Kassis; K A Sproul; N F Schor
Journal:  J Neurosci       Date:  1996-06-15       Impact factor: 6.167

Review 8.  Treatment of pancreatic cancer. Promises and problems of tamoxifen, somatostatin analogs, and gemcitabine.

Authors:  L Rosenberg
Journal:  Int J Pancreatol       Date:  1997-10

9.  Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.

Authors:  H M Ellerby; S J Martin; L M Ellerby; S S Naiem; S Rabizadeh; G S Salvesen; C A Casiano; N R Cashman; D R Green; D E Bredesen
Journal:  J Neurosci       Date:  1997-08-15       Impact factor: 6.167

10.  Estrogen receptor beta (ERbeta) is expressed in brain astrocytic tumors and declines with dedifferentiation of the neoplasm.

Authors:  Anna Batistatou; Dimitrios Stefanou; Anna Goussia; Evdokia Arkoumani; Athanasios G Papavassiliou; Niki J Agnantis
Journal:  J Cancer Res Clin Oncol       Date:  2004-07       Impact factor: 4.553
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.