Literature DB >> 8194514

Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?

W Löscher1, D Schmidt.   

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Year:  1994        PMID: 8194514     DOI: 10.1016/0920-1211(94)90012-4

Source DB:  PubMed          Journal:  Epilepsy Res        ISSN: 0920-1211            Impact factor:   3.045


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  24 in total

1.  Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in mice.

Authors:  Scott A Heldt; Kerry J Ressler
Journal:  J Neurosci       Date:  2010-05-26       Impact factor: 6.167

2.  Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.

Authors:  Trevor H Gilbert; G Campbell Teskey
Journal:  Exp Brain Res       Date:  2007-01-26       Impact factor: 1.972

Review 3.  Measuring human brain GABA in vivo: effects of GABA-transaminase inhibition with vigabatrin.

Authors:  O A Petroff; D L Rothman
Journal:  Mol Neurobiol       Date:  1998-02       Impact factor: 5.590

Review 4.  Antiepileptic drug treatment in the nineties in The Netherlands.

Authors:  D G Kasteleijn-Nolstlt Trenité; P M Edelbroek
Journal:  Pharm World Sci       Date:  1997-04

Review 5.  Retigabine.

Authors:  Roger J Porter; Virinder Nohria; Chris Rundfeldt
Journal:  Neurotherapeutics       Date:  2007-01       Impact factor: 7.620

Review 6.  New avenues for anti-epileptic drug discovery and development.

Authors:  Wolfgang Löscher; Henrik Klitgaard; Roy E Twyman; Dieter Schmidt
Journal:  Nat Rev Drug Discov       Date:  2013-09-20       Impact factor: 84.694

7.  The interactions of nitric oxide and acetylcholine on penicillin-induced epilepsy in rats.

Authors:  Abdullah Hilmi Marangoz; Mehmet Yildirim; Mustafa Ayyildiz; Cafer Marangoz
Journal:  Neurochem Res       Date:  2012-03-08       Impact factor: 3.996

8.  Epilepsy: perampanel-new promise for refractory epilepsy?

Authors:  Wolfgang Löscher; Dieter Schmidt
Journal:  Nat Rev Neurol       Date:  2012-11-13       Impact factor: 42.937

9.  Levetiracetam.

Authors:  M Haria; J A Balfour
Journal:  CNS Drugs       Date:  1997-02       Impact factor: 5.749

Review 10.  The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?

Authors:  Wolfgang Löscher
Journal:  Neurochem Res       Date:  2016-08-08       Impact factor: 3.996

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