Literature DB >> 819414

A method to obtain infusion schedules for prescribed blood concentration time courses.

C S Patlak, K D Pettigrew.   

Abstract

It is sometimes desirable to obtain a specified blood level which obeys a prescribed mathematical form. Following an approach based on impulse analysis via Laplace Transform techniques, a general method for an input injection schedule which will achieve this goal is derived. Specific infusion schedules are given which attain blood levels that are constant, increase linearly, decay exponentially, and increase exponentially. Further, simpler approximate infusion schedules are also derived whose outputs achieve the desired function after a short time. Two illustrative experimental examples-one for [14C]EDTA-Ca in anesthetized rhesus monkeys and the other for 2-deoxy-D-[1-14C]glucose in the conscious rat-are presented in detail. The assumptions are discussed and an error analysis is performed.

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Year:  1976        PMID： 819414     DOI： 10.1152/jappl.1976.40.3.458

Source DB:  PubMed          Journal:  J Appl Physiol        ISSN： 0021-8987            Impact factor:   3.531


  11 in total

1.  Measurement of local cerebral protein synthesis in vivo: influence of recycling of amino acids derived from protein degradation.

Authors:  C B Smith; G E Deibler; N Eng; K Schmidt; L Sokoloff
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

2.  Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity.

Authors:  Ai-Ling Lin; Daniel Coman; Lihong Jiang; Douglas L Rothman; Fahmeed Hyder
Journal:  J Cereb Blood Flow Metab       Date:  2014-07-02       Impact factor: 6.200

3.  Step-down infusions of Gd-DTPA yield greater contrast-enhanced magnetic resonance images of BBB damage in acute stroke than bolus injections.

Authors:  Tavarekere N Nagaraja; Vijaya Nagesh; James R Ewing; Polly A Whitton; Joseph D Fenstermacher; Robert A Knight
Journal:  Magn Reson Imaging       Date:  2006-11-07       Impact factor: 2.546

4.  Role of extracellular proteins in the dynamics of vasogenic brain edema.

Authors:  T Kuroiwa; R Cahn; M Juhler; G Goping; G Campbell; I Klatzo
Journal:  Acta Neuropathol       Date:  1985       Impact factor: 17.088

5.  Use of acute hyperphenylalaninemia in rhesus monkeys to examine sensitivity and stability of the L-[1-11C]leucine method for measurement of regional rates of cerebral protein synthesis with PET.

Authors:  Carolyn B Smith; Kathleen C Schmidt; Shrinivas Bishu; Michael A Channing; Jeff Bacon; Thomas V Burlin; Mei Qin; Zhong-Hua Liu; Zengyan Xia; Tianjiang Huang; Bee-Kee Vuong; Peter Herscovitch
Journal:  J Cereb Blood Flow Metab       Date:  2008-04-23       Impact factor: 6.200

6.  Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[(14)C]DTPA.

Authors:  Robert A Knight; Kishor Karki; James R Ewing; George W Divine; Joseph D Fenstermacher; Clifford S Patlak; Tavarekere N Nagaraja
Journal:  J Cereb Blood Flow Metab       Date:  2009-03-25       Impact factor: 6.200

7.  1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo.

Authors:  D L Rothman; K L Behar; H P Hetherington; J A den Hollander; M R Bendall; O A Petroff; R G Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

8.  Blood-brain barrier disruption and exacerbation of ischemic brain edema after restoration of blood flow in experimental focal cerebral ischemia.

Authors:  T Kuroiwa; M Shibutani; R Okeda
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

9.  In normal rat, intraventricularly administered insulin-like growth factor-1 is rapidly cleared from CSF with limited distribution into brain.

Authors:  Tavarekere N Nagaraja; Padma Patel; Martin Gorski; Peter D Gorevic; Clifford S Patlak; Joseph D Fenstermacher
Journal:  Cerebrospinal Fluid Res       Date:  2005-07-26

10.  A computerized infusion pump for control of tissue tracer concentration during positron emission tomography in vivo pharmacokinetic/pharmacodynamic measurements.

Authors:  Olof Eriksson; Andreas Wallberg; Stina Syvänen; Raymond Josephsson; Bengt Långström; Mats Bergström
Journal:  BMC Med Phys       Date:  2008-05-30
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