Literature DB >> 8194041

Interphase molecular cytogenetics of Ewing's sarcoma and peripheral neuroepithelioma t(11;22) with flanking and overlapping cosmid probes.

C Desmaze1, J Zucman, O Delattre, T Melot, G Thomas, A Aurias.   

Abstract

The translocation, t(11;22)(q24;q12), recurrently observed in Ewing's sarcoma and in peripheral neuroepithelioma has been recently cloned. The analysis of a series of ES/PNE has revealed that the chromosome 22 breakpoints are clustered in a small region of 7 kb, called EWSR1, and that those on chromosome 11 are spread over a larger region of 40-50 kb, called EWSR2. Cosmids from loci flanking or overlapping these two regions have been obtained. We demonstrate here that fluorescence in situ hybridization (FISH) with these cosmids allows the localization of the two breakpoints with a 10-kb resolution and leads to a rapid and reliable ES/PNE diagnosis.

Entities:  

Mesh：

Year:  1994        PMID： 8194041     DOI： 10.1016/0165-4608(94)90022-1

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  7 in total

1.  Inconspicuous insertion 22;12 in myxoid/round cell liposarcoma accompanied by the secondary structural abnormality der(16)t(1;16).

Authors:  Nathan C Birch; Cristina R Antonescu; Marilu Nelson; Lisa Sarran; James R Neff; Thomas Seemayer; Julia A Bridge
Journal:  J Mol Diagn       Date:  2003-08       Impact factor: 5.568

2.  A practical approach to the clinical diagnosis of Ewing's sarcoma/primitive neuroectodermal tumour and other small round cell tumours sharing EWS rearrangement using new fluorescence in situ hybridisation probes for EWSR1 on formalin fixed, paraffin wax embedded tissue.

Authors:  U Yamaguchi; T Hasegawa; Y Morimoto; U Tateishi; M Endo; F Nakatani; A Kawai; H Chuman; Y Beppu; M Endo; H Kurotaki; K Furuta
Journal:  J Clin Pathol       Date:  2005-10       Impact factor: 3.411

3.  Interphase fluorescence in situ hybridization and reverse transcription polymerase chain reaction as a diagnostic aid for synovial sarcoma.

Authors:  J Shipley; J Crew; S Birdsall; S Gill; J Clark; C Fisher; A Kelsey; T Nojima; H Sonobe; C Cooper; B Gusterson
Journal:  Am J Pathol       Date:  1996-02       Impact factor: 4.307

4.  Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing's group.

Authors:  A Mezzelani; S Tornielli; F Minoletti; M A Pierotti; G Sozzi; S Pilotti
Journal:  Br J Cancer       Date:  1999-10       Impact factor: 7.640

5.  Rapid and highly sensitive approach for multiplexed somatic fusion detection.

Authors:  Samuel Abbou; Sarah Finstuen-Magro; Brigit McDannell; Michelle Feenstra; Abigail Ward; David S Shulman; Birgit Geoerger; Joadly Duplan; Hannah Comeau; Katherine A Janeway; Kelly Klega; Brian D Crompton
Journal:  Mod Pathol       Date:  2022-03-28       Impact factor: 8.209

6.  Prognostic impact of chromosomal aberrations in Ewing tumours.

Authors:  C M Hattinger; U Pötschger; M Tarkkanen; J Squire; M Zielenska; S Kiuru-Kuhlefelt; L Kager; P Thorner; S Knuutila; F K Niggli; P F Ambros; H Gadner; D R Betts
Journal:  Br J Cancer       Date:  2002-06-05       Impact factor: 7.640

7.  Progress in the molecular biology of ewing tumors.

Authors:  H Kovar
Journal:  Sarcoma       Date:  1998
  7 in total

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