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Literature DB >> 819248

Increase in basal and thyrotropin-releasing hormone (TRH)-stimulated secretion of thyrotropin (TSH) by passive immunization with antiserum to somatostatin in rats.

Abstract

Passive immunization of rats with an antiserum to synthetic somatostatin caused a 250% elevation of basal serum TSH levels and a nearly 200% increase in TSH-response to TRH. These findings strongly support the concept that pituitary thyrotrophs are regulated by endogenous somatostatin as well as by TRH and thyroid hormones. Serum GH levels in the antiserum-treated rats were considerably higher than those in rats which received normal serum. No clearcut influence on prolactin secretion was observed.

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Year: 1976 PMID： 819248 DOI： 10.1210/endo-98-4-1069

Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 4.736

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Cited

11 in total

1. Effect of active immunization against a recombinant mouse granulocyte-macrophage colony-stimulating factor/somatostatin fusion protein on the growth of mice.

Authors: Bingbing Wu; Ruili Qi; Bin Li; Taoyan Yuan; Heshan Liu; Jun He; Zhiwei Lin; Weifen Li; Yan Fu; Dong Niu
Journal: Mol Biol Rep Date: 2012-02-04 Impact factor: 2.316

2. Prosomatostatin-specific antigen in rat brain: localization by immunocytochemical staining with an antiserum to a synthetic sequence of preprosomatostatin.

Authors: R M Lechan; R H Goodman; M Rosenblatt; S Reichlin; J F Habener
Journal: Proc Natl Acad Sci U S A Date: 1983-05 Impact factor: 11.205

Review 3. Regulation of thyroid-stimulating hormone (TSH) secretion in the fetus and neonate.

Authors: E Roti
Journal: J Endocrinol Invest Date: 1988-02 Impact factor: 4.256

4. Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus.

Authors: Y Hirooka; C S Hollander; S Suzuki; P Ferdinand; S I Juan
Journal: Proc Natl Acad Sci U S A Date: 1978-09 Impact factor: 11.205

5. Release of somatostatin-like immunoreactivity from incubated rat hypothalamus and cerebral cortex. Effects of glucose and glucoregulatory hormones.

Authors: M Berelowitz; D Dudlak; L A Frohman
Journal: J Clin Invest Date: 1982-06 Impact factor: 14.808

Increase in basal and thyrotropin-releasing hormone (TRH)-stimulated secretion of thyrotropin (TSH) by passive immunization with antiserum to somatostatin in rats.

1. Effect of active immunization against a recombinant mouse granulocyte-macrophage colony-stimulating factor/somatostatin fusion protein on the growth of mice.

2. Prosomatostatin-specific antigen in rat brain: localization by immunocytochemical staining with an antiserum to a synthetic sequence of preprosomatostatin.

Review 3. Regulation of thyroid-stimulating hormone (TSH) secretion in the fetus and neonate.

4. Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus.

5. Release of somatostatin-like immunoreactivity from incubated rat hypothalamus and cerebral cortex. Effects of glucose and glucoregulatory hormones.

Review 6. Somatostatin and somatostatin receptor physiology.

7. Morphological equivalent of the bifunctional role of somatostatin.

Review 8. Thyrotropin-secreting pituitary adenomas: epidemiology, diagnosis, and management.

9. Comparative distribution of somatostatin and somatostatin receptors in PTU-induced hypothyroidism.

10. Thyrotropin secretion during oral glucose tolerance test in acromegalic patients and control subjects.