Literature DB >> 8191584

The 3Rs of life: Ras, Raf and growth regulation.

S A Moodie1, A Wolfman.   

Abstract

Cellular Ras proteins are essential elements in normal signal transduction pathways while activated Ras proteins are prevalent in many different forms of human cancers. Here, we discuss the mechanism through which Ras proteins, either cellular or activated, transmit a proliferative signal by activating cytoplasmic serine/threonine kinases.

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Year:  1994        PMID： 8191584     DOI： 10.1016/0168-9525(94)90147-3

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  32 in total

Review 1.  Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.

Authors:  W Kolch
Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

Review 2.  Genetics of hepatocellular carcinoma.

Authors:  Andreas Teufel; Frank Staib; Stephan Kanzler; Arndt Weinmann; Henning Schulze-Bergkamen; Peter-R Galle
Journal:  World J Gastroenterol       Date:  2007-04-28       Impact factor: 5.742

3.  Autoregulation of the Raf-1 serine/threonine kinase.

Authors:  R E Cutler; R M Stephens; M R Saracino; D K Morrison
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205

4.  A screen for genes that function downstream of Ras1 during Drosophila eye development.

Authors:  F D Karim; H C Chang; M Therrien; D A Wassarman; T Laverty; G M Rubin
Journal:  Genetics       Date:  1996-05       Impact factor: 4.562

Review 5.  The discovery of vemurafenib for the treatment of BRAF-mutated metastatic melanoma.

Authors:  Alex Kim; Mark S Cohen
Journal:  Expert Opin Drug Discov       Date:  2016-06-23       Impact factor: 6.098

6.  KSR stimulates Raf-1 activity in a kinase-independent manner.

Authors:  N R Michaud; M Therrien; A Cacace; L C Edsall; S Spiegel; G M Rubin; D K Morrison
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

7.  Depletion of K-Ras promotes proteasome degradation of survivin.

Authors:  Awet Tecleab; Saïd M Sebti
Journal:  Cell Cycle       Date:  2013-01-16       Impact factor: 4.534

Review 8.  Signal transduction by Ras-like GTPases: a potential target for anticancer drugs.

Authors:  M Spaargaren; J R Bischoff; F McCormick
Journal:  Gene Expr       Date:  1995

9.  Negative regulation of Raf-1 by phosphorylation of serine 621.

Authors:  H Mischak; T Seitz; P Janosch; M Eulitz; H Steen; M Schellerer; A Philipp; W Kolch
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

10.  FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice.

Authors:  Sun-Young Lee; Roland Meier; Saori Furuta; Marc E Lenburg; Paraic A Kenny; Ren Xu; Mina J Bissell
Journal:  J Clin Invest       Date:  2012-08-13       Impact factor: 14.808
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