| Literature DB >> 8190210 |
A López de Munain1, A Blanco, J I Emparanza, J F Martí Massó, A Cobo, B Basauri, L Martorell, M Baiget, J M Martínez Lage.
Abstract
We report anticipation in an extensive sample of myotonic dystrophy (MyD) kindreds taken from an epidemiological survey recently conducted in Guipúzcoa, Spain. Analysis of the parent-child pairs ascertained showed a mean anticipation of 2.86 decades (range 0-6). Greater anticipation occurred when the transmissor parent was the mother. These results suggest a possible sex-related effect in the transmission of the MyD gene, and are in agreement with recent discoveries at the molecular level.Entities:
Mesh：
Year: 1994 PMID： 8190210 DOI： 10.1159/000110362
Source DB: PubMed Journal: Neuroepidemiology ISSN： 0251-5350 Impact factor: 3.282