Literature DB >> 8190116

In vitro inhibition of the actions of basic FGF by a novel 16 amino acid peptide.

I Cosic1, A E Drummond, J R Underwood, M T Hearn.   

Abstract

A composite procedure involving molecular modelling and a property-pattern algorithm, the Resonant Recognition Model (RRM), has been applied to structure-function studies with basic fibroblast growth factor (bFGF). Property-pattern characteristics for biological activity and receptor recognition for a group of FGF-related proteins were defined and then used to aid the design of a set of peptides which can act as bFGF antagonists. Molecular modelling techniques were then employed to identify the peptide within this set with the greatest conformational similarity to the putative receptor domain of bFGF. This 16 amino acid residue peptide (16mer), which exhibits no sequence homology to bFGF, antagonised the stimulatory effect of bFGF on fibroblast [3H]thymidine incorporation and cell proliferation, but exerted no effect itself in these in vitro bioassays.

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Year:  1994        PMID： 8190116     DOI： 10.1007/bf01084262

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  33 in total

1.  Basic fibroblast growth factor induces angiogenesis in vitro.

Authors:  R Montesano; J D Vassalli; A Baird; R Guillemin; L Orci
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

2.  Purification and characterization of heparin-binding endothelial cell growth factors.

Authors:  R Lobb; J Sasse; R Sullivan; Y Shing; P D'Amore; J Jacobs; M Klagsbrun
Journal:  J Biol Chem       Date:  1986-02-05       Impact factor: 5.157

3.  Adenosine 3',5'-monophosphate mediates both the mitogenic effect of thyrotropin and its ability to amplify the response to insulin-like growth factor I in FRTL5 cells.

Authors:  D Tramontano; A C Moses; B M Veneziani; S H Ingbar
Journal:  Endocrinology       Date:  1988-01       Impact factor: 4.736

Review 4.  Relation of vascular proliferation to tumor growth.

Authors:  J Folkman; R Cotran
Journal:  Int Rev Exp Pathol       Date:  1976

5.  Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential.

Authors:  P Delli-Bovi; A M Curatola; K M Newman; Y Sato; D Moscatelli; R M Hewick; D B Rifkin; C Basilico
Journal:  Mol Cell Biol       Date:  1988-07       Impact factor: 4.272

6.  Heparin protects basic and acidic FGF from inactivation.

Authors:  D Gospodarowicz; J Cheng
Journal:  J Cell Physiol       Date:  1986-09       Impact factor: 6.384

7.  Studies on protein-DNA interactions using the resonant recognition model. Application to repressors and transforming proteins.

Authors:  I Cosic; M T Hearn
Journal:  Eur J Biochem       Date:  1992-04-15

8.  Mesoderm induction in early Xenopus embryos by heparin-binding growth factors.

Authors:  J M Slack; B G Darlington; J K Heath; S F Godsave
Journal:  Nature       Date:  1987 Mar 12-18       Impact factor: 49.962

9.  Direct inhibition of rat granulosa cell inhibin production by epidermal growth factor in vitro.

Authors:  Z W Zhang; A C Herington; R S Carson; J K Findlay; H G Burger
Journal:  Mol Cell Endocrinol       Date:  1987-12       Impact factor: 4.102

10.  Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

Authors:  O Saksela; D Moscatelli; A Sommer; D B Rifkin
Journal:  J Cell Biol       Date:  1988-08       Impact factor: 10.539
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  8 in total

1.  Ataxin active site determination using spectral distribution of electron ion interaction potentials of amino acids.

Authors:  E Pirogova; V Vojisavljevic; J L Hernández Cáceres; I Cosic
Journal:  Med Biol Eng Comput       Date:  2010-02-11       Impact factor: 2.602

2.  In vitro growth suppression of human glioma cells by a 16-mer oligopeptide: a potential new treatment modality for malignant glioma.

Authors:  Katsuhiko Kono; Tetsuya Ueba; Jun A Takahashi; Nozomu Murai; Nobuo Hashimoto; Akira Myoumoto; Nobuo Itoh; Manabu Fukumoto
Journal:  J Neurooncol       Date:  2003-06       Impact factor: 4.130

3.  Biological effects of a de novo designed myxoma virus peptide analogue: evaluation of cytotoxicity on tumor cells.

Authors:  Taghrid S Istivan; Elena Pirogova; Emily Gan; Nahlah M Almansour; Peter J Coloe; Irena Cosic
Journal:  PLoS One       Date:  2011-09-19       Impact factor: 3.240

4.  Exploiting Surface Plasmon Resonance (SPR) Technology for the Identification of Fibroblast Growth Factor-2 (FGF2) Antagonists Endowed with Antiangiogenic Activity.

Authors:  Marco Rusnati; Antonella Bugatti; Stefania Mitola; Daria Leali; Paolo Bergese; Laura E Depero; Marco Presta
Journal:  Sensors (Basel)       Date:  2009-08-20       Impact factor: 3.576

5.  Induction of human immunodeficiency virus (HIV-1) envelope specific cell-mediated immunity by a non-homologous synthetic peptide.

Authors:  Ammar Achour; Jean-Michel Biquard; Velibor Krsmanovic; Jean-Pierre M'bika; Damien Ficheux; Marianna Sikorska; Alain J Cozzone
Journal:  PLoS One       Date:  2007-11-28       Impact factor: 3.240

6.  Bioactive peptide design using the Resonant Recognition Model.

Authors:  Irena Cosic; Elena Pirogova
Journal:  Nonlinear Biomed Phys       Date:  2007-07-19

7.  Fibroblast growth factor 2-antagonist activity of a long-pentraxin 3-derived anti-angiogenic pentapeptide.

Authors:  Daria Leali; Roberta Bianchi; Antonella Bugatti; Stefania Nicoli; Stefania Mitola; Laura Ragona; Simona Tomaselli; Grazia Gallo; Sergio Catello; Vincenzo Rivieccio; Lucia Zetta; Marco Presta
Journal:  J Cell Mol Med       Date:  2010-07-20       Impact factor: 5.310

8.  Environmental Light and Its Relationship with Electromagnetic Resonances of Biomolecular Interactions, as Predicted by the Resonant Recognition Model.

Authors:  Irena Cosic; Drasko Cosic; Katarina Lazar
Journal:  Int J Environ Res Public Health       Date:  2016-06-29       Impact factor: 3.390
  8 in total

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