Literature DB >> 818999

Inhibition of leucyl-transfer ribonucleic acid synthetasymol.

A Ogilvie, K Wiebauer, W Kersten.   

Abstract

The bacteriostatic effect of low concentrations of the antibiotic granaticin on Bacillus subtilis is relieved by the addition leucine to the growth medium. In cells treated with granaticin, aminoacylation of leucine tRNA is specifically decreased, but the content of free leucine is not. It is concluded that granaticin interferes with the charging process of leucine tRNA in B. subtilis leading to leucine auxotrophy.

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Year:  1975        PMID： 818999      PMCID： PMC1172503          DOI： 10.1042/bj1520511

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  Magic spot metabolism in an Escherichia coli mutant temperature sensitive in elongation factor Ts.

Authors:  K Glazier; D Schlessinger
Journal:  J Bacteriol       Date:  1974-03       Impact factor: 3.490

Review 2.  Physiology and genetics of the "ribonucleic acid control" locus in escherichia coli.

Authors:  G Edlin; P Broda
Journal:  Bacteriol Rev       Date:  1968-09

3.  [Metabolic products of microorganisms. 5l. On the mechanism of action of borrelidin-inhibition of the threonine incorporation in sRNA].

Authors:  R Hütter; K Poralla; H G Zachau; H Zähner
Journal:  Biochem Z       Date:  1966-03-28

4.  Ribosome formation by puromycin-treated Bacillus subtilis.

Authors:  D Nakada
Journal:  Biochim Biophys Acta       Date:  1965-07-15

Review 5.  Roles of amino acid activating enzymes in cellular physiology.

Authors:  F C Neidhardt
Journal:  Bacteriol Rev       Date:  1966-12

6.  Effect of Borrelidin on the threonyl-tRNA-synthetase activity and the regulation of threonine-biosynthetic enzymes in Saccharomyces cerivisiae.

Authors:  G Nass; R Hasenbank
Journal:  Mol Gen Genet       Date:  1970

7.  Inhibition of leucyl-tRNA synthetase in Escherichia coli by the cytostatic 5,8-dioxo-6-amino-7-chloroquinoline.

Authors:  A Ogilvie; K Wiebauer; P Spitzbarth; W Kersten
Journal:  Biochim Biophys Acta       Date:  1975-10-15

8.  Stringent control of ribonucleic acid synthesis in Bacillus subtilis treated with granaticin.

Authors:  A Ogilvie; K Wiebauer; W Kersten
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

9.  Histidine regulation in Salmonella typhimurium. XI. The percentage of transfer RNA His charged in vivo and its relation to the repression of the histidine operon.

Authors:  J A Lewis; B N Ames
Journal:  J Mol Biol       Date:  1972-04-28       Impact factor: 5.469

10.  Characterization of altered forms of glycyl transfer ribonucleic acid synthetase and the effects of such alterations on aminoacyl transfer ribonucleic acid synthesis in vivo.

Authors:  W R Folk; P Berg
Journal:  J Bacteriol       Date:  1970-04       Impact factor: 3.490
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  15 in total

1.  Effect of granaticin on the activity of DNA-directed RNA polymerase from Streptomyces granaticolor.

Authors:  J Smardová; J Spízek; J Stastná; M Klégr
Journal:  Folia Microbiol (Praha)       Date:  1989       Impact factor: 2.099

2.  Regulation of amino acid transport in growing cells of Streptomyces hydrogenans. I. Modulation of transport capacity and amino acid pool composition during the growth cycle.

Authors:  W Langheinrich; K Ring
Journal:  Arch Microbiol       Date:  1976-09-01       Impact factor: 2.552

3.  Effect of ethanol on rat brain protein synthesis. I. Acute administration.

Authors:  B Goertz
Journal:  Exp Brain Res       Date:  1982       Impact factor: 1.972

4.  Response of guanosine 5'-triphosphate concentration to nutritional changes and its significance for Bacillus subtilis sporulation.

Authors:  J M Lopez; A Dromerick; E Freese
Journal:  J Bacteriol       Date:  1981-05       Impact factor: 3.490

5.  Stringent control of ribonucleic acid synthesis in Bacillus subtilis treated with granaticin.

Authors:  A Ogilvie; K Wiebauer; W Kersten
Journal:  Biochem J       Date:  1975-12       Impact factor: 3.857

6.  Stringent response of Bacillus stearothermophilus: evidence for the existence of two distinct guanosine 3',5'-polyphosphate synthetases.

Authors:  S Fehr; D Richter
Journal:  J Bacteriol       Date:  1981-01       Impact factor: 3.490

7.  The stringent response to unacylated tRNA, energy-and temperature-downshift in Bacillus stearothermophilus.

Authors:  S Fehr; D Richter
Journal:  Arch Microbiol       Date:  1981-03       Impact factor: 2.552

8.  The role of guanosine-3',5'-bis-pyrophosphate in mediating antimicrobial activity of the antibiotic 3,5-dihydroxy-4-ethyl-trans-stilbene.

Authors:  L Sundar; F N Chang
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

9.  Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid.

Authors:  J Hughes; G Mellows
Journal:  Biochem J       Date:  1978-10-15       Impact factor: 3.857

10.  Selective Inhibition of Bacterial Tryptophanyl-tRNA Synthetases by Indolmycin Is Mechanism-based.

Authors:  Tishan L Williams; Yuhui W Yin; Charles W Carter
Journal:  J Biol Chem       Date:  2015-11-09       Impact factor: 5.157
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