Literature DB >> 8189726

A clinical model of genetic influences in alcohol dependence.

M A Schuckit1.   

Abstract

This essay presents a clinical model of the role of genetic factors in alcohol dependence. Data supporting a strong impact of environmental influences along with genetic heterogeneity and the absence of simple Mendelian models combine to produce a complex situation. In light of these complications, this essay presents a model developed by the author's research group focusing on the decreased reaction to alcohol as an important risk factor. The biological contributors might be polygenic or dominant with incomplete penetrance and must interact with environment. The application of this approach to other risk factors is set forth.

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Year:  1994        PMID： 8189726     DOI： 10.15288/jsa.1994.55.5

Source DB:  PubMed          Journal:  J Stud Alcohol        ISSN： 0096-882X


  20 in total

Review 1.  Substance abuse in children and adolescents.

Authors:  B M Tripathi; R Lal
Journal:  Indian J Pediatr       Date:  1999 Jul-Aug       Impact factor: 1.967

2.  Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice.

Authors:  K J Buck; P Metten; J K Belknap; J C Crabbe
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

3.  Genome-wide scan for self-rating of the effects of alcohol in American Indians.

Authors:  Cindy L Ehlers; Ian R Gizer; Marc A Schuckit; Kirk C Wilhelmsen
Journal:  Psychiatr Genet       Date:  2010-10       Impact factor: 2.458

4.  Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2.

Authors:  K Demarest; J McCaughran; E Mahjubi; L Cipp; R Hitzemann
Journal:  J Neurosci       Date:  1999-01-15       Impact factor: 6.167

5.  Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of cocaine self-administered directly into the nucleus accumbens shell.

Authors:  Simon N Katner; Scott M Oster; Zheng-Ming Ding; Gerald A Deehan; Jamie E Toalston; Sheketha R Hauser; William J McBride; Zachary A Rodd
Journal:  Pharmacol Biochem Behav       Date:  2011-06-25       Impact factor: 3.533

6.  Alcohol attenuates load-related activation during a working memory task: relation to level of response to alcohol.

Authors:  Martin P Paulus; Susan F Tapert; Carmen Pulido; Marc A Schuckit
Journal:  Alcohol Clin Exp Res       Date:  2006-08       Impact factor: 3.455

7.  Linkage scan of alcohol dependence in the UCSF Family Alcoholism Study.

Authors:  Ian R Gizer; Cindy L Ehlers; Cassandra Vieten; Kimberly L Seaton-Smith; Heidi S Feiler; James V Lee; Samantha K Segall; David A Gilder; Kirk C Wilhelmsen
Journal:  Drug Alcohol Depend       Date:  2011-01-15       Impact factor: 4.492

Review 8.  [The NMDA receptor system: genetic risk factor for alcoholism].

Authors:  G Schumann; C Saam; A Heinz; K Mann; J Treutlein
Journal:  Nervenarzt       Date:  2005-11       Impact factor: 1.214

9.  Restraint stress and exogenous corticosterone differentially alter sensitivity to the sedative-hypnotic effects of ethanol in inbred long-sleep and inbred short-sleep mice.

Authors:  Clarissa Carlin Parker; Heather Ponicsan; Robert Leon Spencer; Andrew Holmes; Thomas Eugene Johnson
Journal:  Alcohol       Date:  2008-09       Impact factor: 2.405

10.  Microarray analysis of mouse brain gene expression following acute ethanol treatment.

Authors:  Julie A Treadwell; Shiva M Singh
Journal:  Neurochem Res       Date:  2004-02       Impact factor: 3.996
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