| Literature DB >> 8189539 |
W L Marshall1, E S Mittler, P Avery, J P Lawrence, R W Finberg.
Abstract
Despite equivalent p24 antigen production, HSB-2 T cells expressing glycosylphosphatidylinositol (GPi)-linked CD4 were productively infected without cell death or syncytium formation, unlike HSB-2 transfectants expressing wild-type CD4 (wtCD4). HSB-2 transfectants dually expressing wtCD4 and GPi-linked CD4 formed syncytia and died. Thus, wtCD4 expression is critical for human immunodeficiency virus cytopathic effect in HSB-2 transfectants.Entities:
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Year: 1994 PMID: 8189539 PMCID: PMC236913
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103