OBJECTIVES: To assess the relationship between haematocrit and risk of major ischaemic heart disease events. DESIGN: Prospective study of a cohort of men followed up for 9.5 years. SETTING: General practices in 24 towns in England, Wales, and Scotland (British Regional Heart Study). SUBJECTS: Altogether 7735 men aged 40-59 years at screening, who were selected at random from one general practice in each of 24 towns, were studied. MAIN OUTCOME MEASURES: Fatal and nonfatal ischaemic heart disease events. RESULTS: Risk of major ischaemic heart disease events was significantly increased at haematocrit levels of > or = 46.0%. Men with raised haematocrit (> or = 46.0%) showed a 30% increase in relative risk (RR) of major ischaemic heart disease events (RR = 1.32; 95% confidence intervals (CI) 1.10,1.57, p < 0.01) compared with those with values below 46.0%, even after adjustment for age, social class, smoking, body mass index, physical activity, blood cholesterol, lung function (FEV1), and pre-existing evidence of ischaemic heart disease. Further adjustment for systolic blood pressure reduced the risk slightly (RR = 1.27; 95% CI 1.06,1.51, p = 0.02) but it remained significant. The relationship was seen in men with and without pre-existing evidence of ischaemic heart disease. The study suggests that an increased haematocrit level plays a part in the development of major ischaemic heart disease events.
OBJECTIVES: To assess the relationship between haematocrit and risk of major ischaemic heart disease events. DESIGN: Prospective study of a cohort of men followed up for 9.5 years. SETTING: General practices in 24 towns in England, Wales, and Scotland (British Regional Heart Study). SUBJECTS: Altogether 7735 men aged 40-59 years at screening, who were selected at random from one general practice in each of 24 towns, were studied. MAIN OUTCOME MEASURES: Fatal and nonfatal ischaemic heart disease events. RESULTS: Risk of major ischaemic heart disease events was significantly increased at haematocrit levels of > or = 46.0%. Men with raised haematocrit (> or = 46.0%) showed a 30% increase in relative risk (RR) of major ischaemic heart disease events (RR = 1.32; 95% confidence intervals (CI) 1.10,1.57, p < 0.01) compared with those with values below 46.0%, even after adjustment for age, social class, smoking, body mass index, physical activity, blood cholesterol, lung function (FEV1), and pre-existing evidence of ischaemic heart disease. Further adjustment for systolic blood pressure reduced the risk slightly (RR = 1.27; 95% CI 1.06,1.51, p = 0.02) but it remained significant. The relationship was seen in men with and without pre-existing evidence of ischaemic heart disease. The study suggests that an increased haematocrit level plays a part in the development of major ischaemic heart disease events.
Authors: Channing J Paller; Meredith S Shiels; Sabine Rohrmann; Andy Menke; Nader Rifai; William G Nelson; Elizabeth A Platz; Adrian S Dobs Journal: J Androl Date: 2012-05-17
Authors: Bethany L Walton; Marcus Lehmann; Tyler Skorczewski; Lori A Holle; Joan D Beckman; Jeremy A Cribb; Micah J Mooberry; Adam R Wufsus; Brian C Cooley; Jonathan W Homeister; Rafal Pawlinski; Michael R Falvo; Nigel S Key; Aaron L Fogelson; Keith B Neeves; Alisa S Wolberg Journal: Blood Date: 2017-03-01 Impact factor: 22.113