BACKGROUND: Psoriasis vulgaris may benefit from treatment with fumaric acid and/or its derivatives; however, because different preparations have been used, results have been contradictory and difficult to interpret. OBJECTIVE: The purpose of this clinical trial was to evaluate the therapeutic value of fumaric acid derivatives. METHODS: A randomized double-blind study was carried out in patients with psoriasis, comparing a well-characterized formulation of fumaric acid derivatives withplacebo. RESULTS: The results indicated statistically significant superiority of the fumaric acid derivatives over placebo. Adverse events (flush, gastrointestinal disturbances) were initially relatively frequent, but decreased thereafter. CONCLUSION:Fumaric acid derivatives were found to be effective and safe in the treatment of psoriasis.
RCT Entities:
BACKGROUND:Psoriasis vulgaris may benefit from treatment with fumaric acid and/or its derivatives; however, because different preparations have been used, results have been contradictory and difficult to interpret. OBJECTIVE: The purpose of this clinical trial was to evaluate the therapeutic value of fumaric acid derivatives. METHODS: A randomized double-blind study was carried out in patients with psoriasis, comparing a well-characterized formulation of fumaric acid derivatives with placebo. RESULTS: The results indicated statistically significant superiority of the fumaric acid derivatives over placebo. Adverse events (flush, gastrointestinal disturbances) were initially relatively frequent, but decreased thereafter. CONCLUSION:Fumaric acid derivatives were found to be effective and safe in the treatment of psoriasis.
Authors: Nicolle H R Litjens; Jacobus Burggraaf; Elisabeth van Strijen; Co van Gulpen; Herman Mattie; Rik C Schoemaker; Jaap T van Dissel; H Bing Thio; Peter H Nibbering Journal: Br J Clin Pharmacol Date: 2004-10 Impact factor: 4.335
Authors: K Asadullah; W Sterry; K Stephanek; D Jasulaitis; M Leupold; H Audring; H D Volk; W D Döcke Journal: J Clin Invest Date: 1998-02-15 Impact factor: 14.808
Authors: Vittorio Calabrese; Carolin Cornelius; Albena T Dinkova-Kostova; Edward J Calabrese; Mark P Mattson Journal: Antioxid Redox Signal Date: 2010-08-28 Impact factor: 8.401