Literature DB >> 8187732

Some comments on potency measures in mutagenicity research.

B H Margolin1, B S Kim, M G Smith, B A Fetterman, W W Piegorsch, E Zeiger.   

Abstract

In this article, the measurement of the potency of a chemical or mixture from its dose response in a particular assay is addressed. Attention is focused on data from the Ames Salmonella assay. Three measures of potency are explored and shown to be highly correlated. The presentation then discusses specific areas of research that might benefit from a study of potency.

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Year:  1994        PMID： 8187732      PMCID： PMC1566913          DOI： 10.1289/ehp.94102s191

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  7 in total

1.  Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: confirmation of earlier results with 41 additional chemicals.

Authors:  E Zeiger; J K Haseman; M D Shelby; B H Margolin; R W Tennant
Journal:  Environ Mol Mutagen       Date:  1990       Impact factor: 3.216

2.  Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.

Authors:  R W Tennant; B H Margolin; M D Shelby; E Zeiger; J K Haseman; J Spalding; W Caspary; M Resnick; S Stasiewicz; B Anderson
Journal:  Science       Date:  1987-05-22       Impact factor: 47.728

3.  Handling antineoplastic agents: urine mutagenicity in nurses.

Authors:  B Rogers; E A Emmett
Journal:  Image J Nurs Sch       Date:  1987

4.  Prediction of environmental carcinogens: a strategy for the mid-1980s.

Authors:  H S Rosenkranz; G Klopman; V Chankong; J Pet-Edwards; Y Y Haimes
Journal:  Environ Mutagen       Date:  1984

5.  An empirical approach to the statistical analysis of mutagenesis data from the Salmonella test.

Authors:  L Bernstein; J Kaldor; J McCann; M C Pike
Journal:  Mutat Res       Date:  1982-08       Impact factor: 2.433

6.  Statistical analysis of the Ames Salmonella/microsome test.

Authors:  B H Margolin; N Kaplan; E Zeiger
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

7.  Exploring relationships between mutagenic and carcinogenic potencies.

Authors:  W W Piegorsch; D G Hoel
Journal:  Mutat Res       Date:  1988-09       Impact factor: 2.433
  7 in total
  1 in total

1.  Measurement of DNA repair deficiency in workers exposed to benzene.

Authors:  L M Hallberg; R el Zein; L Grossman; W W Au
Journal:  Environ Health Perspect       Date:  1996-05       Impact factor: 9.031
  1 in total

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