Literature DB >> 818749

Effect of beta-adrenergic blockade with propranolol on cerebral blood flow, autoregulation and CO2 responsiveness.

M Aqyagi, V D Deshmukh, J S Meyer, Y Kawamura, Y Tagashira.   

Abstract

Cerebral autoregulation and vasomotor responsiveness to carbon dioxide were measured quantitatively in normal baboons and after intravertebral or intravenous of the beta-adrenergic blocking agent, propranolol hydrochloride (Inderal). Continuous measurements were made of cerebral blood flow (CBF: measured as bilateral internal jugular venous outflow using an electromagnetic flowmeter), cerebral perfusion pressure (CPP), arterial Po2 and Pco2 and venous Po2, cerebral arteriovenous oxygen difference and endotracheal Pco2. The autoregulation index (A.I. = deltaCBF/deltaCPP) and the chemical index (C.I.= deltaCBF/deltaPaco2), were used as quantitative measures.

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Year:  1976        PMID: 818749     DOI: 10.1161/01.str.7.3.291

Source DB:  PubMed          Journal:  Stroke        ISSN: 0039-2499            Impact factor:   7.914


  5 in total

1.  The effect of beta-adrenergic receptor blocking drugs on cerebral blood flow.

Authors:  D N Griffith; I M James; P A Newbury; M L Woollard
Journal:  Br J Clin Pharmacol       Date:  1979-05       Impact factor: 4.335

Review 2.  Heterogeneous impact of hypotension on organ perfusion and outcomes: a narrative review.

Authors:  Lingzhong Meng
Journal:  Br J Anaesth       Date:  2021-08-12       Impact factor: 9.166

3.  Effect of propranolol treatment in pregnant rats on motor activity and avoidance learning of the offspring.

Authors:  Z Speiser; A Shved; S Gitter
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

4.  Monitoring the Evolution of Asynchrony between Mean Arterial Pressure and Mean Cerebral Blood Flow via Cross-Entropy Methods.

Authors:  Alberto Porta; Francesca Gelpi; Vlasta Bari; Beatrice Cairo; Beatrice De Maria; Cora May Panzetti; Noemi Cornara; Enrico Giuseppe Bertoldo; Valentina Fiolo; Edward Callus; Carlo De Vincentiis; Marianna Volpe; Raffaella Molfetta; Valeria Pistuddi; Marco Ranucci
Journal:  Entropy (Basel)       Date:  2022-01-02       Impact factor: 2.524

5.  Metoprolol Impairs β1-Adrenergic Receptor-Mediated Vasodilation in Rat Cerebral Arteries: Implications for β-Blocker Therapy.

Authors:  Christopher L Moore; David S Henry; Samantha J McClenahan; Kelly K Ball; Nancy J Rusch; Sung W Rhee
Journal:  J Pharmacol Exp Ther       Date:  2020-10-25       Impact factor: 4.030

  5 in total

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