| Literature DB >> 818706 |
A J Matas, D E Sutherland, M W Steffes, S M Mauer, A Sowe, R L Simmons, J S Najarian.
Abstract
A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme uridine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.Entities:
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Year: 1976 PMID： 818706 DOI： 10.1126/science.818706
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728