Literature DB >> 81861

Secretion rate independent evaluation of IgM antibody avidity at the level of single immunocytes.

G Doria, C Mancini, C DeLisi.   

Abstract

The hemolytic plaque inhibition assay has been performed on spleen cells from mice immunized with TNP-HRBC to evaluate avidity of anti-TNP IgM antibodies. At different times after immunization direct plaques were inhibited by soluble TNP-EACA, TNP61-BGG, or anti-mu antiserum. Analysis of the inhibition data provided independent estimates of antibody avidity and secretion rate. Avidity was found to increase with time, to reach a maximum when the antibody response attained the peak value, and then to decline as the response was waning. There was a decrease followed by increase of the secretion rate concomitant with the rise and fall of the antibody response and avidity.

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Year:  1978        PMID： 81861

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  4 in total

1.  Immunoresponses to Neisseria meningitidis epitopes: in vivo analysis of immunocompetent cells involved in suppression of secondary response to phosphorylcholine.

Authors:  J Faro; R Seoane; I Lareo; A Eiras; M Schiller; B J Regueiro
Journal:  Med Microbiol Immunol       Date:  1987       Impact factor: 3.402

2.  T-cell-dependent oscillations of IgM antibody affinity during the immune response to DNP-Dextran to low or high epitope density.

Authors:  L Nencioni; C Mancini; C Pini; G Doria
Journal:  Immunology       Date:  1982-09       Impact factor: 7.397

3.  Immunoresponses to Neisseria meningitidis epitopes: suppression of secondary response to phosphorylcholine is carrier specific.

Authors:  J Faro; R Seoane; A Eiras; I Lareo; J Couceiro; B J Regueiro
Journal:  Infect Immun       Date:  1986-01       Impact factor: 3.441

4.  Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. I. Occurrence in AKR/J and BALB/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen cells.

Authors:  A F Schrater; E A Goidl; G J Thorbecke; G W Siskind
Journal:  J Exp Med       Date:  1979-07-01       Impact factor: 14.307
  4 in total

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