Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Interaction between tolbutamide and ketoconazole in healthy subjects.

Literature DB >> 8186066

Interaction between tolbutamide and ketoconazole in healthy subjects.

Y S Krishnaiah¹, S Satyanarayana, D Visweswaram.

Abstract

A possible interaction between tolbutamide and ketoconazole was studied in seven healthy volunteers. Treatment for 1 week with 200 mg oral ketoconazole increased the elimination half-life (from mean +/- s.d. 3.7 +/- 0.4 to 12.3 +/- 1.9 h) and AUC(0.12 h) of tolbutamide (from 309 +/- 27 to 546 +/- 20 micrograms ml-1 h) by 25 +/- 64 and 66 +/- 15%, respectively. The percentage blood glucose reduction was also increased when tolbutamide and ketoconazole were coadministered.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1994 PMID： 8186066 PMCID： PMC1364599 DOI： 10.1111/j.1365-2125.1994.tb04262.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

2 in total

1. Determination of tolbutamide and chlorpropamide in biological fluids.

Authors: S B Matin; M Rowland
Journal: J Pharm Pharmacol Date: 1973-02 Impact factor: 3.765

2. In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines.

Authors: D J Back; J F Tjia; J Karbwang; J Colbert
Journal: Br J Clin Pharmacol Date: 1988-07 Impact factor: 4.335

2 in total

9 in total

1. Predicting drug candidate victims of drug-drug interactions, using microdosing.

Authors: Marie Croft; Brendan Keely; Ian Morris; Lan Tann; Graham Lappin
Journal: Clin Pharmacokinet Date: 2012-04-01 Impact factor: 6.447

Review 2. Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.

Authors: K Venkatakrishnan; L L von Moltke; D J Greenblatt
Journal: Clin Pharmacokinet Date: 2000-02 Impact factor: 6.447

Review 3. Pharmacokinetics of antifungal agents in onychomycoses.

Authors: D Debruyne; A Coquerel
Journal: Clin Pharmacokinet Date: 2001 Impact factor: 6.447

Review 4. Importance of multi-p450 inhibition in drug-drug interactions: evaluation of incidence, inhibition magnitude, and prediction from in vitro data.

Authors: Nina Isoherranen; Justin D Lutz; Sophie P Chung; Houda Hachad; Rene H Levy; Isabelle Ragueneau-Majlessi
Journal: Chem Res Toxicol Date: 2012-09-27 Impact factor: 3.739

Interaction between tolbutamide and ketoconazole in healthy subjects.

1. Determination of tolbutamide and chlorpropamide in biological fluids.

2. In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines.

1. Predicting drug candidate victims of drug-drug interactions, using microdosing.

Review 2. Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.

Review 3. Pharmacokinetics of antifungal agents in onychomycoses.

Review 4. Importance of multi-p450 inhibition in drug-drug interactions: evaluation of incidence, inhibition magnitude, and prediction from in vitro data.

Review 5. Systemic antifungal agents. Drug interactions of clinical significance.

Review 6. Drug-induced hypoglycaemia: an update.

7. Effect of ketoconazole on the pharmacokinetics of rosiglitazone in healthy subjects.

Review 8. Pharmacotherapy of type 2 diabetes mellitus: an update on drug-drug interactions.

9. Drug-drug interaction between voriconazole and oral hypoglycemic agents in diabetic rats.