Literature DB >> 8185611

Identification of the mouse helper T lymphocyte differentiation antigen 3G11 as the ganglioside IV3(NeuAc)2-GgOse4Cer.

F Dittrich1, K Hayakawa, M Nimtz, F Ebel, P F Mühlradt.   

Abstract

The 3G11 antigen, originally defined by the monoclonal antibody SM3G11, is expressed to different extents by distinct murine CD4+ T helper cell subsets. This antigen was isolated from a 3G11+ murine thymoma by lipid extraction. Upon further purification 3G11 antigen was enriched in the disialoganglioside fraction and was finally purified by HPLC. Compositional and methylation analysis, liquid secondary ion mass spectroscopy (LSI-MS) and comparison with an authentic sample resulted in identification of the 3G11 antigen as the disialoganglioside IV3(NeuAc)2-GgOse4Cer.

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Year:  1994        PMID: 8185611     DOI: 10.1006/bbrc.1994.1628

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  5 in total

1.  Targeting ganglioside epitope 3G11 on the surface of CD4+ T cells suppresses EAE by altering the Treg/Th17 cell balance.

Authors:  Zhao Zhao; Bogoljub Ciric; Shuo Yu; Guang-Xian Zhang; Abdolmohamad Rostami
Journal:  Int Immunol       Date:  2010-08-02       Impact factor: 4.823

2.  Expression of 3G11 epitope defines subpopulations of regulatory T cells with different suppressive potency.

Authors:  Zhao Zhao; Bogoljub Ciric; Shuo Yu; Hongmei Li; Jingxian Yang; Malek Kamoun; Guang-Xian Zhang; Abdolmohamad Rostami
Journal:  J Neurol Sci       Date:  2010-06-08       Impact factor: 3.181

3.  Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.

Authors:  J Müthing
Journal:  Glycoconj J       Date:  1997-02       Impact factor: 2.916

4.  9-O-Acetylation of sialomucins: a novel marker of murine CD4 T cells that is regulated during maturation and activation.

Authors:  M Krishna; A Varki
Journal:  J Exp Med       Date:  1997-06-02       Impact factor: 14.307

5.  Establishment of cells exhibiting mutated glycolipid synthesis from mouse thymus by immortalization with SV-40 virus.

Authors:  Masao Iwamori; Yuriko Iwamori
Journal:  Glycoconj J       Date:  2005-11       Impact factor: 3.009

  5 in total

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