Literature DB >> 8185570

Molecular cloning, expression, and characterization of a fifth melanocortin receptor.

I Gantz1, Y Shimoto, Y Konda, H Miwa, C J Dickinson, T Yamada.   

Abstract

We report the isolation of a gene encoding a novel member of the family of melanocortin receptors. The mouse melanocortin-5 receptor (mMC5R) responds to melanocortins with an increase in intracellular cyclic 3',5'-adenosine monophosphate (cAMP) concentrations. Stimulation of the mMC5R by the melanocortins revealed a hierarchy of potency in which alpha-melanocyte stimulating hormone (alpha-MSH) > beta-melanocyte stimulating hormone (beta-MSH) > adrenocorticotropic hormone (ACTH) > gamma- melanocyte stimulating hormone (gamma-MSH). Further structure-activity studies indicated that amino- and carboxyl-terminal portions of alpha-MSH appear to be key determinants in the activation of mMC5R whereas the melanocortin core heptapeptide sequence is devoid of pharmacological activity. Northern blot analysis demonstrated the expression of mMC5R mRNA in mouse skeletal muscle, lung, spleen, and brain.

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Year:  1994        PMID： 8185570     DOI： 10.1006/bbrc.1994.1580

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  65 in total

1.  Relevance of the C-terminal Arg-Phe sequence in gamma(2)-melanocyte-stimulating hormone (gamma(2)-MSH) for inducing cardiovascular effects in conscious rats.

Authors:  M J Nijsen; G J de Ruiter; C M Kasbergen; P Hoogerhout; D J de Wildt
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

Review 2.  Alan [corrected] N. Epstein award: Intracellular signaling and ingestive behaviors.

Authors:  Derek Daniels
Journal:  Physiol Behav       Date:  2010-03-25

Review 3.  The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases.

Authors:  Minying Cai; Victor J Hruby
Journal:  Curr Protein Pept Sci       Date:  2016       Impact factor: 3.272

4.  A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands.

Authors:  Mark D Ericson; Katie T Freeman; Sathya M Schnell; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2017-01-17       Impact factor: 7.446

5.  Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position.

Authors:  Paolo Grieco; Minying Cai; Alexander V Mayorov; Dev Trivedi; Victor J Hruby
Journal:  Peptides       Date:  2005-11-21       Impact factor: 3.750

6.  Synthesis and Pharmacology of α/β(3)-Peptides Based on the Melanocortin Agonist Ac-His-dPhe-Arg-Trp-NH2 Sequence.

Authors:  Anamika Singh; Srinivasa R Tala; Viktor Flores; Katie Freeman; Carrie Haskell-Luevano
Journal:  ACS Med Chem Lett       Date:  2015-04-08       Impact factor: 4.345

7.  Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor.

Authors:  Paolo Grieco; Diego Brancaccio; Ettore Novellino; Victor J Hruby; Alfonso Carotenuto
Journal:  Eur J Med Chem       Date:  2011-05-23       Impact factor: 6.514

8.  Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists.

Authors:  Katlyn A Fleming; Katie T Freeman; Mark D Ericson; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2018-08-16       Impact factor: 7.446

9.  Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling.

Authors:  Min Chen; Charles J Aprahamian; Robert A Kesterson; Carroll M Harmon; Yingkui Yang
Journal:  Biochemistry       Date:  2007-09-18       Impact factor: 3.162

10.  Alpha-MSH rescues neurons from excitotoxic cell death.

Authors:  Asa Forslin Aronsson; Stefan Spulber; Mircea Oprica; Bengt Winblad; Claes Post; Marianne Schultzberg
Journal:  J Mol Neurosci       Date:  2007-04-17       Impact factor: 3.444
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