Latex agglutination and adenoviruses. II. Detection of antigens.

Latex particles were coated with different monoclonal antibodies (MAbs) reacting with different epitopes of the hexons of adenovirus (AV) type h1 and h35. The coated particles were tested with the purified hexon of 22 different mammalian AV types and were agglutinated by the respective hexon antigen(s) with high specificity. The sensitivity of the reaction was influenced by the amount of MAb adsorbed to latex particles. The latex, coated with a MAb of genus specific reactivity can be a valuable tool in the rapid immunodiagnosis of adenovirus infections.