Literature DB >> 8184549

The E6 gene of human papillomavirus type 16 is sufficient for transformation of baby rat kidney cells in cotransfection with activated Ha-ras.

Z Liu1, J Ghai, R S Ostrow, R C McGlennen, A J Faras.   

Abstract

The transforming potential of the E6 open reading frame (ORF) of the human papillomavirus type 16 was investigated with transformation assays in cotransfections with an activated ras gene. The E6 ORF driven by the heterologous CMV promoter could fully transform baby rat kidney cells (BRK) in cooperation with ras. The transformed cells grew in soft agar and induced tumors in athymic nude mice. The E6 ORF with mutations at the splicing donor site, which only encodes the full length E6 but not E6*s, could also fully transform the BRK cells at a similar efficiency as the wild-type E6 ORF, indicating that the full-length E6 was sufficient for the transformed phenotype.

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Year:  1994        PMID： 8184549     DOI： 10.1006/viro.1994.1306

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  13 in total

1.  HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter function.

Authors:  Xuefeng Liu; Jeffrey Roberts; Aleksandra Dakic; Yiyu Zhang; Richard Schlegel
Journal:  Virology       Date:  2008-03-26       Impact factor: 3.616

2.  Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16.

Authors:  L Sherman; R Schlegel
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

3.  A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo.

Authors:  Marie Nguyen; Shiyu Song; Amy Liem; Elliot Androphy; Yun Liu; Paul F Lambert
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

4.  Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype.

Authors:  R B Ray; L M Lagging; K Meyer; R Ray
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

5.  Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts.

Authors:  Wenyi Wei; Wendy A Jobling; Wen Chen; William C Hahn; John M Sedivy
Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272

6.  Human papillomavirus E6 proteins mediate resistance to interferon-induced growth arrest through inhibition of p53 acetylation.

Authors:  Christy Hebner; Melanie Beglin; Laimonis A Laimins
Journal:  J Virol       Date:  2007-09-26       Impact factor: 5.103

7.  The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium.

Authors:  Andrew C Hoover; William C Spanos; George F Harris; Mary E Anderson; Aloysius J Klingelhutz; John H Lee
Journal:  Arch Otolaryngol Head Neck Surg       Date:  2007-05

8.  Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation.

Authors:  M C Stöppler; K Ching; H Stöppler; K Clancy; R Schlegel; J Icenogle
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

9.  Normal human fibroblasts are resistant to RAS-induced senescence.

Authors:  Jennifer A Benanti; Denise A Galloway
Journal:  Mol Cell Biol       Date:  2004-04       Impact factor: 4.272

Review 10.  Senescence induction; a possible cancer therapy.

Authors:  Matilde E Lleonart; Ana Artero-Castro; Hiroshi Kondoh
Journal:  Mol Cancer       Date:  2009-01-08       Impact factor: 27.401
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