Literature DB >> 8183438

Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons.

M R Young1, S M Fleetwood-Walker, R Mitchell, F E Munro.   

Abstract

Several antagonists at metabotropic glutamate (mGlu) receptors, when applied ionophoretically, inhibited the excitation of single dorsal horn neurons elicited by cutaneous administration of the C fibre-selective algogen, mustard oil. The selectivity and stereospecificity of AP3 isomers at mGlu, compared to NMDA receptors was confirmed on responses to agonists and matched by their effects on mustard oil-evoked activity.

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Year:  1994        PMID： 8183438     DOI： 10.1016/0028-3908(94)90109-0

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  15 in total

1.  Metabotropic glutamate and cannabinoid receptor crosstalk in periaqueductal grey pain processing.

Authors:  E Palazzos; V de Novellis; I Marabese; F Rossi; S Maione
Journal:  Curr Neuropharmacol       Date:  2006-07       Impact factor: 7.363

2.  Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats.

Authors:  M E Fundytus; K Yashpal; J G Chabot; M G Osborne; C D Lefebvre; A Dray; J L Henry; T J Coderre
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

3.  Peripheral metabotropic glutamate receptor subtype 5 contributes to inflammation-induced hypersensitivity of the rat temporomandibular joint.

Authors:  Bo Li; Li Lu; Xuexin Tan; Ming Zhong; Yan Guo; Xin Yi
Journal:  J Mol Neurosci       Date:  2013-06-27       Impact factor: 3.444

Review 4.  Glutamate receptors and nociception: implications for the drug treatment of pain.

Authors:  M E Fundytus
Journal:  CNS Drugs       Date:  2001-01       Impact factor: 5.749

5.  Stimulatory effects of the putative metabotropic glutamate receptor antagonist L-AP3 on phosphoinositide turnover in neonatal rat cerebral cortex.

Authors:  R Mistry; G Prabhu; M Godwin; R A Challiss
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

6.  The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles.

Authors:  Geoffrey B Varty; Mariagrazia Grilli; Angelo Forlani; Silva Fredduzzi; Michael E Grzelak; Donald H Guthrie; Robert A Hodgson; Sherry X Lu; Elisa Nicolussi; Annamarie J Pond; Eric M Parker; John C Hunter; Guy A Higgins; Angelo Reggiani; Rosalia Bertorelli
Journal:  Psychopharmacology (Berl)       Date:  2005-01-29       Impact factor: 4.530

7.  The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat.

Authors:  Li Ping Zhang; Ying Chen; Barry P Clark; Emanuele Sher; Karin N Westlund
Journal:  J Pain       Date:  2000       Impact factor: 5.820

8.  Antisense ablation of type I metabotropic glutamate receptor mGluR1 inhibits spinal nociceptive transmission.

Authors:  M R Young; G Blackburn-Munro; T Dickinson; M J Johnson; H Anderson; I Nakalembe; S M Fleetwood-Walker
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

Review 9.  Central sensitization: a generator of pain hypersensitivity by central neural plasticity.

Authors:  Alban Latremoliere; Clifford J Woolf
Journal:  J Pain       Date:  2009-09       Impact factor: 5.820

10.  Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain.

Authors:  Ji-Qing Li; Shao-Rui Chen; Hong Chen; You-Qing Cai; Hui-Lin Pan
Journal:  J Neurochem       Date:  2009-10-15       Impact factor: 5.372
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