Literature DB >> 8183423

Muscarinic receptor-mediated increase in zeta-PKC expression in SK-N-SH human neuroblastoma cells.

J Baumgold1, K D Dyer.   

Abstract

Anti-peptide antibodies specific for each protein kinase C (PKC) isozyme were used to screen SK-N-SH human neuroblastoma cells. These cells were found to express only alpha- and zeta-PKC. Stimulation of these cells with phorbol esters caused alpha- but not zeta-PKC to translocate from cytosolic to membrane fractions. Stimulation of these cells with carbachol, which releases inositol trisphosphate and diacylglycerol, caused a transient translocation of alpha-PKC but not of zeta-PKC. Carbachol did, however, cause a gradual increase in immunoreactive zeta-PKC which reached maximal values 10-20 min after stimulation. These results implicate zeta-PKC in a receptor-mediated signalling event.

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Year:  1994        PMID： 8183423     DOI： 10.1007/bf00966807

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  17 in total

1.  A putative M3 muscarinic cholinergic receptor of high molecular weight couples to phosphoinositide hydrolysis in human SK-N-SH neuroblastoma cells.

Authors:  S K Fisher; A M Heacock
Journal:  J Neurochem       Date:  1988-03       Impact factor: 5.372

Review 2.  Protein kinase C.

Authors:  S Stabel; P J Parker
Journal:  Pharmacol Ther       Date:  1991       Impact factor: 12.310

3.  Protein kinase C group B members PKC-delta, -epsilon, -zeta and PKC-L(eta). Comparison of properties of recombinant proteins in vitro and in vivo.

Authors:  M Liyanage; D Frith; E Livneh; S Stabel
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

Review 4.  The molecular heterogeneity of protein kinase C and its implications for cellular regulation.

Authors:  Y Nishizuka
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

5.  The complete primary structure of protein kinase C--the major phorbol ester receptor.

Authors:  P J Parker; L Coussens; N Totty; L Rhee; S Young; E Chen; S Stabel; M D Waterfield; A Ullrich
Journal:  Science       Date:  1986-08-22       Impact factor: 47.728

6.  Phosphatidylinositol turnover in neuroblastoma cells: regulation by bradykinin, acetylcholine, but not mu- and delta-opioid receptors.

Authors:  V C Yu; W Sadée
Journal:  Neurosci Lett       Date:  1986-11-11       Impact factor: 3.046

7.  Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells.

Authors:  B R Conklin; M R Brann; N J Buckley; A L Ma; T I Bonner; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

8.  Effect of phorbol esters on protein kinase C-zeta.

Authors:  D K Ways; P P Cook; C Webster; P J Parker
Journal:  J Biol Chem       Date:  1992-03-05       Impact factor: 5.157

9.  Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes.

Authors:  I Dominguez; M T Diaz-Meco; M M Municio; E Berra; A García de Herreros; M E Cornet; L Sanz; J Moscat
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272

10.  Calcium independence of phosphoinositide hydrolysis-induced increase in cyclic AMP accumulation in SK-N-SH human neuroblastoma cells.

Authors:  J Baumgold; R Paek; G Fiskum
Journal:  J Neurochem       Date:  1992-05       Impact factor: 5.372
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  1 in total

1.  Phorbol ester stimulation of phosphatidylcholine synthesis in four cultured neural cell lines: correlations with expression of protein kinase C isoforms.

Authors:  S A Sproull; S C Morash; D M Byers; H W Cook
Journal:  Neurochem Res       Date:  1995-12       Impact factor: 3.996
  1 in total

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