Literature DB >> 8183366

Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit.

J Rettig1, S H Heinemann, F Wunder, C Lorra, D N Parcej, J O Dolly, O Pongs.   

Abstract

Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, poreforming alpha-subunits and a peripheral beta-subunit. We have cloned a beta-subunit (Kv beta 1) that is specifically expressed in the rat nervous system. Association of Kv beta 1 with alpha-subunits confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the Kv beta 1 amino terminus.

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Year:  1994        PMID： 8183366     DOI： 10.1038/369289a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  278 in total

1.  Xenopus embryonic spinal neurons express potassium channel Kvbeta subunits.

Authors:  M A Lazaroff; A D Hofmann; A B Ribera
Journal:  J Neurosci       Date:  1999-12-15       Impact factor: 6.167

2.  Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation.

Authors:  D Kerschensteiner; M Stocker
Journal:  Biophys J       Date:  1999-07       Impact factor: 4.033

3.  Subfamily-specific posttranscriptional mechanism underlies K(+) channel expression in a developing neuronal blastomere.

Authors:  F Ono; Y Katsuyama; K Nakajo; Y Okamura
Journal:  J Neurosci       Date:  1999-08-15       Impact factor: 6.167

4.  Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning.

Authors:  K P Giese; J F Storm; D Reuter; N B Fedorov; L R Shao; T Leicher; O Pongs; A J Silva
Journal:  Learn Mem       Date:  1998 Sep-Oct       Impact factor: 2.460

5.  Coregulation of voltage-dependent kinetics of Na(+) and K(+) currents in electric organ.

Authors:  M L McAnelly; H H Zakon
Journal:  J Neurosci       Date:  2000-05-01       Impact factor: 6.167

Review 6.  Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium.

Authors:  J M Nerbonne
Journal:  J Physiol       Date:  2000-06-01       Impact factor: 5.182

7.  A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels.

Authors:  T M Weiger; M H Holmqvist; I B Levitan; F T Clark; S Sprague; W J Huang; P Ge; C Wang; D Lawson; M E Jurman; M A Glucksmann; I Silos-Santiago; P S DiStefano; R Curtis
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

8.  Kv4.2 mRNA abundance and A-type K(+) current amplitude are linearly related in basal ganglia and basal forebrain neurons.

Authors:  T Tkatch; G Baranauskas; D J Surmeier
Journal:  J Neurosci       Date:  2000-01-15       Impact factor: 6.167

9.  Direct interaction of a brain voltage-gated K+ channel with syntaxin 1A: functional impact on channel gating.

Authors:  O Fili; I Michaelevski; Y Bledi; D Chikvashvili; D Singer-Lahat; H Boshwitz; M Linial; I Lotan
Journal:  J Neurosci       Date:  2001-03-15       Impact factor: 6.167

10.  Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog.

Authors:  M Wallner; P Meera; L Toro
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205
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