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Literature DB >> 818336

A genetic polymorphism in the constant region of rabbit b4 kappa chains.

Abstract

Amino acid sequence analysis of a b4 light chain from a rabbit homogeneous antistreptococcal antibody revealed the presence of two amino acid substitutions in the constant region not previously reported for these positions. These interchanges, consisting of serine for alanine at position 121 and leucine for glutamine at position 124, were also present in about 30% of the pooled b4 light chains isolated from pooled IgG from the rabbit (4539) that produced the homogeneous antibody. In addition, these interchanges (b4var) were found, always at the same levels, in varying percentages in nonimmune or early immune bleedings from related rabbits in this pedigreed family and could be traced for five generations. The inheritance pattern of b4var was consistent with autosomal codominant inheritance.

Entities: Mutation Species

Mesh：

Substances：

Year: 1976 PMID： 818336 PMCID： PMC2190215 DOI： 10.1084/jem.143.6.1475

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

28 in total

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Journal: Science Date: 1964-07-24 Impact factor: 47.728

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Journal: Biochem J Date: 1963-08 Impact factor: 3.857

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Authors: K J Fraser; K Pulsen; E Haber
Journal: Biochemistry Date: 1972-12-19 Impact factor: 3.162

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Authors: A D Strosberg; C Hamers-Casterman; W Van der Loo; R Hamers
Journal: J Immunol Date: 1974-10 Impact factor: 5.422

5. Amino acid sequence of rabbit pneumococcal antibody. I. Light-chain cysteine-containing peptides.

Authors: A D Strosberg; K J Fraser; M N Margolies; E Haber
Journal: Biochemistry Date: 1972-12-19 Impact factor: 3.162

6. Serologic identity of the b4 allotypic determinants present on homogeneous rabbit light chains with different N-terminal amino acid sequences.

Authors: T J Kindt; R K Seide; H Lackland; A L Thunberg
Journal: J Immunol Date: 1972-10 Impact factor: 5.422

7. Idiotypic cross-reactions among anti-streptococcal antibodies in an inbred rabbit population.

Authors: D G Klapper; T J Kindt
Journal: Scand J Immunol Date: 1974 Impact factor: 3.487

Review 8. The search for antibodies with molecular uniformity.

Authors: R M Krause
Journal: Adv Immunol Date: 1970 Impact factor: 3.543

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Authors: J C Jaton
Journal: Biochem J Date: 1974-07 Impact factor: 3.857

10. Allotypy of rabbit serum proteins. I. Immuno-chemical analysis leading to the individualization of seven main allotypes.

Authors: J OUDIN
Journal: J Exp Med Date: 1960-07-01 Impact factor: 14.307

12 in total

1. Characterization and DNA sequence of the b6w2 allotype of the rabbit immunoglobulin kappa 1 light chain (b locus).

Authors: W van der Loo; C E Bouton; M Sanchez; F Mougel; E Castién; R Hamers; M Monnerot
Journal: Immunogenetics Date: 1995 Impact factor: 2.846

2. Complex allotypes of the rabbit immunoglobulin kappa light chains are encoded by structural alleles.

Authors: M A Akimenko; O Heidmann; F Rougeon
Journal: Nucleic Acids Res Date: 1984-06-11 Impact factor: 16.971

3. The sequences of rabbit kappa light chains of b4 and b5 allotypes differ more in their constant regions than in their 3' untranslated regions.

Authors: K E Bernstein; R M Skurla; R G Mage
Journal: Nucleic Acids Res Date: 1983-10-25 Impact factor: 16.971

4. The primary structure of the constant region of Basilea-rabbit immunoglobulin lambda-chains.

Authors: I Garcia; J C Jaton
Journal: Biochem J Date: 1981-07-01 Impact factor: 3.857

5. Structural analysis of a rabbit immunoglobulin kappa 2 J-C locus reveals multiple deletions.

Authors: L Emorine; E E Max
Journal: Nucleic Acids Res Date: 1983-12-20 Impact factor: 16.971

6. Estimation of gene diversity at the b locus of the constant region of the immunoglobulin light chain in natural populations of European rabbit (Oryctolagus cuniculus) in Portugal, Andalusia and on the Azorean Islands.

Authors: W van der Loo; N Ferrand; R C Soriguer
Journal: Genetics Date: 1991-04 Impact factor: 4.562

7. Evolution of the rabbit immunoglobulin kappa chain genes.

Authors: H Ayadi; P N Marche; P A Cazenave
Journal: Immunogenetics Date: 1991 Impact factor: 2.846

8. Nucleotide sequence of constant and 3' untranslated regions of a kappa immunoglobulin light chain mRNA of a homozygous b4 rabbit.

Authors: O Heidmann; C Auffray; P A Cazenave; F Rougeon
Journal: Proc Natl Acad Sci U S A Date: 1981-09 Impact factor: 11.205

9. BASILEA rabbits express two types of immunoglobulin light chains: lambda and kappa-like.

Authors: I Garcia; D C Brandt; A Benammar; P A Cazenave; J C Jaton
Journal: Proc Natl Acad Sci U S A Date: 1982-07 Impact factor: 11.205

10. Structural studies on protein products of murine chromosome 17: partial amino acid sequence of an H-2Kb molecule.

Authors: J D Capra; E S Vitetta; D G Klapper; J W Uhr; J Klein
Journal: Proc Natl Acad Sci U S A Date: 1976-10 Impact factor: 11.205