| Literature DB >> 8182649 |
R B Stricker1, B Barlogie, D D Kiprov.
Abstract
Therapeutic use of interferon-alpha (IFN-alpha) has been associated with the development of a variety of autoimmune disorders. We describe a patient who received chronic treatment with IFN-alpha following autologous bone marrow transplantation for multiple myeloma. The patient developed an antibody inhibitor directed against factor VIII coagulant protein (FVIIIC) leading to a fatal hemorrhagic diathesis. The association between IFN-alpha therapy and autoimmune complications deserves wider recognition and further study.Entities:
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Year: 1994 PMID: 8182649
Source DB: PubMed Journal: J Rheumatol ISSN: 0315-162X Impact factor: 4.666