Literature DB >> 8182640

The molecular weight of therapeutic hyaluronan (sodium hyaluronate): how significant is it?

A D Aviad1, J B Houpt.   

Abstract

Various molecular weight hyaluronic acid (HA) preparations have been injected into joints for the treatment of human and equine osteoarthritis. A therapeutic advantage has been claimed for commercial products with a molecular weight in the range found in normal synovial fluid (SF), compared to lower molecular weight products. But a correlation between molecular weight and efficacy is not borne out by an analysis of the available literature on clinical results. SF viscosity, HA concentration, HA molecular weight and rate of synthesis in joint disease. It is proposed that the beneficial effect of injected HA in joint disease may be due to pharmacological rather than to physical properties.

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Year:  1994        PMID： 8182640

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  11 in total

1.  Intra-articular hyaluronan treatment for osteoarthritis.

Authors:  E George
Journal:  Ann Rheum Dis       Date:  1998-11       Impact factor: 19.103

2.  A prospective randomised controlled clinical trial comparing the efficacy of different molecular weight hyaluronan solutions in the treatment of knee osteoarthritis.

Authors:  Nurdan Kotevoglu; Pinar Cakil Iyibozkurt; Ozcan Hiz; Hasan Toktas; Banu Kuran
Journal:  Rheumatol Int       Date:  2005-06-15       Impact factor: 2.631

Review 3.  A risk-benefit assessment of injections of hyaluronan and its derivatives in the treatment of osteoarthritis of the knee.

Authors:  M E Adams; A J Lussier; J G Peyron
Journal:  Drug Saf       Date:  2000-08       Impact factor: 5.606

Review 4.  Viscosupplementation for the treatment of osteoarthritis of the knee.

Authors:  N Bellamy; J Campbell; V Robinson; T Gee; R Bourne; G Wells
Journal:  Cochrane Database Syst Rev       Date:  2006-04-19

5.  Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee.

Authors:  Benjamin A McArthur; Christopher J Dy; Peter D Fabricant; Alejandro Gonzalez Della Valle
Journal:  Patient Prefer Adherence       Date:  2012-12-12       Impact factor: 2.711

6.  Treatment of adhesive capsulitis with intra-articular hyaluronate: A systematic review.

Authors:  Joshua D Harris; Michael J Griesser; Alex Copelan; Grant L Jones
Journal:  Int J Shoulder Surg       Date:  2011-04

7.  The safety and efficacy of intra-articular dual molecular weighted hyaluronic Acid in the treatment of knee osteoarthritis: the I.d.e.h.a. Study.

Authors:  Xuming Shen; Romeo Gatti
Journal:  Orthop Rev (Pavia)       Date:  2013-12-10

8.  Hylan GF-20 Viscosupplementation in the Treatment of Symptomatic Osteoarthritis of the Knee: Clinical Effect Survivorship at 5 Years.

Authors:  Tarek Boutefnouchet; Guru Puranik; Esther Holmes; Karl M Bell
Journal:  Knee Surg Relat Res       Date:  2017-06-01

9.  The association between different molecular weights of hyaluronic acid and CHAD, HIF-1α, COL2A1 expression in chondrocyte cultures.

Authors:  Duygu Yasar Sirin; Necati Kaplan; Ibrahim Yilmaz; Numan Karaarslan; Hanefi Ozbek; Yener Akyuva; Yasin Emre Kaya; Kadir Oznam; Nuray Akkaya; Olcay Guler; Semih Akkaya; Mahir Mahirogullari
Journal:  Exp Ther Med       Date:  2018-03-09       Impact factor: 2.447

10.  A single intra-articular injection of 2.0% non-chemically modified sodium hyaluronate vs 0.8% hylan G-F 20 in the treatment of symptomatic knee osteoarthritis: A 6-month, multicenter, randomized, controlled non-inferiority trial.

Authors:  Emmanuel Maheu; Bernard Avouac; Renée Liliane Dreiser; Thomas Bardin
Journal:  PLoS One       Date:  2019-12-10       Impact factor: 3.240
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