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Literature DB >> 8181855

Inhibition of tumour promotion by various palm-oil tocotrienols.

S H Goh¹, N F Hew, A W Norhanom, M Yadav.

Abstract

Inhibition of tumour promotion by various vitamin E compounds (tocopherols and tocotrienols) and some of their dimers was examined by an in vitro assay utilizing the activation of Epstein-Barr virus (EBV) early antigen (EA) expression in EBV-genome-carrying human lymphoblastoid cells. The results reveal that gamma- and delta-tocotrienols derived from palm oil exhibit a strong activity against tumour promotion by inhibiting EBV EA expression in Raji cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). However, alpha- and gamma-tocopherols and dimers of gamma-tocotrienol or gamma-tocopherol lack this activity.

Entities: Chemical Disease Species

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Year: 1994 PMID： 8181855 DOI： 10.1002/ijc.2910570415

Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396

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Cited

17 in total

1. Application of supercritical fluid chromatography in the quantitative analysis of minor components (carotenes, vitamin E, sterols, and squalene) from palm oil.

Authors: Yuen May Choo; Mei Han Ng; Ah Ngan Ma; Cheng Hock Chuah; Mohd Ali Hashim
Journal: Lipids Date: 2005-04 Impact factor: 1.880

2. Tocotrienols fight cancer by targeting multiple cell signaling pathways.

Authors: Ramaswamy Kannappan; Subash C Gupta; Ji Hye Kim; Bharat B Aggarwal
Journal: Genes Nutr Date: 2011-04-09 Impact factor: 5.523

3. Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes.

Authors: J P Kamat; H D Sarma; T P Devasagayam; K Nesaretnam; Y Basiron
Journal: Mol Cell Biochem Date: 1997-05 Impact factor: 3.396

Inhibition of tumour promotion by various palm-oil tocotrienols.

1. Application of supercritical fluid chromatography in the quantitative analysis of minor components (carotenes, vitamin E, sterols, and squalene) from palm oil.

2. Tocotrienols fight cancer by targeting multiple cell signaling pathways.

3. Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes.

4. γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death.

5. The neuroprotective effects of tocotrienol rich fraction and alpha tocopherol against glutamate injury in astrocytes.

6. Synergistic anticancer effects of combined γ-tocotrienol with statin or receptor tyrosine kinase inhibitor treatment.

Review 7. Tocotrienols: Vitamin E beyond tocopherols.

8. Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats.

9. Dietary terpenoids and prostate cancer chemoprevention.

Review 10. Tocotrienols: the emerging face of natural vitamin E.