| Literature DB >> 8181540 |
M D Aceto1, S M Scates, Z Ji, E R Bowman.
Abstract
Nicotine produced antinociception in mice which was antagonized noncompetitively by naloxone. In addition, at significantly lower doses, nicotine noncompetitively antagonized morphine-induced antinociception. A speculative suggestion regarding the opiatergic and anti-opiatergic actions of nicotine is that it significantly promotes and maintains smoking behavior.Entities:
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Year: 1993 PMID: 8181540 DOI: 10.1016/0926-6917(93)90009-f
Source DB: PubMed Journal: Eur J Pharmacol ISSN: 0014-2999 Impact factor: 4.432