Literature DB >> 8181059

The human interferon alpha/beta receptor: characterization and molecular cloning.

D Novick1, B Cohen, M Rubinstein.   

Abstract

We describe a universal ligand-binding receptor for human interferons alpha and interferon beta (type I IFNs). A soluble 40 kDa IFN-alpha/beta receptor (p40) that blocks the activity of type I IFNs was purified from urine and sequenced. Antibodies raised against p40 completely block the activity of several type I IFNs and immuno-precipitate both a cellular 102 kDa IFN-alpha/beta receptor and its cross-linked complexes with IFN-alpha 2. The receptor is a disulfide-linked dimer, consisting of 51 kDa subunits. We isolated and expressed a 1.5 kb cDNA, coding for the IFN-alpha/beta receptor. Its 331 amino acid sequence includes a leader and a transmembrane region, while its ectodomain corresponds to p40. IFN-alpha/beta receptor is physically associated with the cytoplasmic Tyr kinase JAK1, hence, in addition to ligand binding, it is directly involved in signal transduction.

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Year:  1994        PMID： 8181059     DOI： 10.1016/0092-8674(94)90154-6

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  130 in total

1.  Characterization of a soluble ternary complex formed between human interferon-beta-1a and its receptor chains.

Authors:  R M Arduini; K L Strauch; L A Runkel; M M Carlson; X Hronowski; S F Foley; C N Young; W Cheng; P S Hochman; D P Baker
Journal:  Protein Sci       Date:  1999-09       Impact factor: 6.725

Review 2.  Molecular mechanisms in T helper phenotype development.

Authors:  J D Farrar; S H Ranganath; K M Murphy
Journal:  Springer Semin Immunopathol       Date:  1999

3.  The intracellular domain of interferon-alpha receptor 2c (IFN-alphaR2c) chain is responsible for Stat activation.

Authors:  S V Kotenko; L S Izotova; O V Mirochnitchenko; C Lee; S Pestka
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

4.  Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking.

Authors:  L C Roisman; J Piehler; J Y Trosset; H A Scheraga; G Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-06       Impact factor: 11.205

5.  IFNalpha/beta promotes cell survival by activating NF-kappa B.

Authors:  C H Yang; A Murti; S R Pfeffer; L Basu; J G Kim; L M Pfeffer
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

6.  Expression of type I interferon receptor in liver and peripheral blood mononuclear cells in chronic hepatitis C patients.

Authors:  Yuhki Yamaguchi; Keisuke Hino; Daisuke Fujiwara; Fenyu Ren; Yoshiharu Katoh; Yasuhiro Satoh; Kiwamu Okita
Journal:  Dig Dis Sci       Date:  2002-07       Impact factor: 3.199

7.  Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha.

Authors:  Raj Deonarain; Amit Verma; Andrew C G Porter; Dirk R Gewert; Leonidas C Platanias; Eleanor N Fish
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-03       Impact factor: 11.205

8.  Mouse STAT2 restricts early dengue virus replication.

Authors:  Joseph Ashour; Juliet Morrison; Maudry Laurent-Rolle; Alan Belicha-Villanueva; Courtney Ray Plumlee; Dabeiba Bernal-Rubio; Katherine L Williams; Eva Harris; Ana Fernandez-Sesma; Christian Schindler; Adolfo García-Sastre
Journal:  Cell Host Microbe       Date:  2010-11-18       Impact factor: 21.023

9.  The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor.

Authors:  M C Gauzzi; G Barbieri; M F Richter; G Uzé; L Ling; M Fellous; S Pellegrini
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-28       Impact factor: 11.205

10.  Expression and signaling specificity of the IFNAR chain of the type I interferon receptor complex.

Authors:  S N Constantinescu; E Croze; A Murti; C Wang; L Basu; D Hollander; D Russell-Harde; M Betts; V Garcia-Martinez; J E Mullersman; L M Pfeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205
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