| Literature DB >> 8180590 |
U Hørding1, H W Nielsen, H Albeck, S Daugaard.
Abstract
The polymerase chain reaction was used to examine paraffin-embedded tissues of 37 nasopharyngeal carcinomas (NPC) for Epstein-Barr virus (EBV) genomic sequences. EBV DNA was found in 2/14 keratinising squamous cell (WHO 1) carcinomas and in all of 23 non-keratinising and undifferentiated (WHO 2 and 3) NPC. The study confirms the infrequent association of keratinising NPC and EBV, in contrast with the 100% association of the less differentiated NPCs and the virus. The results may indicate a different carcinogenesis for the WHO 1 NPC subtype.Entities:
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Year: 1993 PMID： 8180590 DOI： 10.1016/0964-1955(93)90036-e
Source DB: PubMed Journal: Eur J Cancer B Oral Oncol ISSN： 0964-1955