Gene therapy for vascular diseases.

Gene transfer by virus- and liposome-mediated vectors has potential for treating genetic diseases, cancer, and cardiovascular diseases. In this article, we discuss the general principle and techniques for gene transfer and the specific issues facing therapy for vascular diseases. We also propose a strategy for using virus-mediated gene transfer to restore the vasoprotective function of the vascular wall, thereby preventing vascular thrombosis. Experimental data from ongoing work in our laboratories are presented to illustrate the importance of this approach in vascular gene transfer therapy.