OBJECTIVE: The neuropathologic mechanisms of the ovine fetal brain in response to several hours of sustained hypoxemia with variable degrees of metabolic acidemia was investigated in both the preterm and near-term ovine fetus. STUDY DESIGN: Three groups of fetuses were studied in each of the near-term and midgestation groups: a hypoxic group, a control group, and an uninstrumented control group. Histopathologic studies were performed after a 40-hour recovery period after experimentation. RESULTS: Pathologic findings consisted of predominately white matter damage with some adjacent cortical necrosis but no selective neuronal injury. In the near-term group the hypoxia group fetuses demonstrated significantly higher white matter injury scores than did control group fetuses (p < 0.05). Periventricular white matter injury was the predominant pattern seen in the midgestation group. CONCLUSIONS: In spite of normalization of biophysical and biochemical parameters after hypoxemia both midgestation and near-term fetuses sustained pathologic changes. Presence or extent of injury did not correlate with the degree of hypoxemia or metabolic acidosis achieved.
OBJECTIVE: The neuropathologic mechanisms of the ovine fetal brain in response to several hours of sustained hypoxemia with variable degrees of metabolic acidemia was investigated in both the preterm and near-term ovine fetus. STUDY DESIGN: Three groups of fetuses were studied in each of the near-term and midgestation groups: a hypoxic group, a control group, and an uninstrumented control group. Histopathologic studies were performed after a 40-hour recovery period after experimentation. RESULTS: Pathologic findings consisted of predominately white matter damage with some adjacent cortical necrosis but no selective neuronal injury. In the near-term group the hypoxia group fetuses demonstrated significantly higher white matter injury scores than did control group fetuses (p < 0.05). Periventricular white matter injury was the predominant pattern seen in the midgestation group. CONCLUSIONS: In spite of normalization of biophysical and biochemical parameters after hypoxemia both midgestation and near-term fetuses sustained pathologic changes. Presence or extent of injury did not correlate with the degree of hypoxemia or metabolic acidosis achieved.
Authors: Kendall M Lawrence; Samson Hennessy-Strahs; Patrick E McGovern; Ali Y Mejaddam; Avery C Rossidis; Heron D Baumgarten; Esha Bansal; Maryann Villeda; Jiancheng Han; Zhongshan Gou; Sheng Zhao; Jack Rychik; William H Peranteau; Marcus G Davey; Alan W Flake; J William Gaynor; Carlo R Bartoli Journal: JCI Insight Date: 2018-12-20
Authors: Carmen Rey-Santano; Victoria E Mielgo; Elena Gastiasoro; Xabier Murgia; Hector Lafuente; Estibaliz Ruiz-Del-Yerro; Adolf Valls-I-Soler; Enrique Hilario; Francisco J Alvarez Journal: Front Neurosci Date: 2011-09-20 Impact factor: 4.677
Authors: Pablo Castaño; Miguel Fuertes; Ignacio Ferre; Miguel Fernández; Maria del Carmen Ferreras; Javier Moreno-Gonzalo; Camino González-Lanza; Frank Katzer; Javier Regidor-Cerrillo; Luis Miguel Ortega-Mora; Valentín Pérez; Julio Benavides Journal: Vet Res Date: 2014-01-29 Impact factor: 3.683