Literature DB >> 8178679

Obstetric complications in histories of monozygotic twins discordant and concordant for schizophrenia.

T F McNeil1, E Cantor-Graae, E F Torrey, K Sjöström, A Bowler, E Taylor, R Rawlings, E S Higgins.   

Abstract

Histories of obstetric complications (OCs) during pregnancy, labor-delivery and the neonatal period were investigated by detailed maternal report for 23 monozygotic (MZ) twin pairs discordant for schizophrenia, 10 MZ twin pairs concordant for schizophrenia and 7 normal MZ control pairs. Statistically significant differences in OC rates were found across these 3 groups. OCs being most frequent in discordant pairs and least frequent in normal control pairs. Labor complications were significantly more frequent in discordant than concordant pairs. OC rates were equivalent in sick and well discordant twins. The results provide evidence for the role of OCs in the development of schizophrenia, complications at the time of birth being especially associated with the development of schizophrenia in discordant twins.

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Year:  1994        PMID： 8178679     DOI： 10.1111/j.1600-0447.1994.tb08092.x

Source DB:  PubMed          Journal:  Acta Psychiatr Scand        ISSN： 0001-690X            Impact factor:   6.392


  14 in total

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10.  Neurodevelopmental concepts of schizophrenia in the genome-wide association era: AKT/mTOR signaling as a pathological mediator of genetic and environmental programming during development.

Authors:  Kristy R Howell; Amanda J Law
Journal:  Schizophr Res       Date:  2019-09-12       Impact factor: 4.939
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