Literature DB >> 8178433

Pathogenesis of SIVmac infection in Chinese and Indian rhesus macaques: effects of splenectomy on virus burden.

S V Joag1, E B Stephens, R J Adams, L Foresman, O Narayan.   

Abstract

The spleen and lymph nodes are the predominant sites of viral replication in SIV and HIV infections. We studied splenectomized and control unsplenectomized rhesus macaques of both the Indian and the Chinese subspecies of Macaca mulatta. All animals were inoculated with SIVmac239, a molecularly cloned strain of SIV. Our data showed: (1) splenectomized animals, particularly among the Indian subspecies, had a lower virus burden and longer survival than unsplenectomized controls, (2) the Chinese macaques controlled virus replication more effectively than did the Indian animals, and (3) that a higher infectious virus burden was present in LN/spleen than in blood in both splenectomized and control animals.

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Year:  1994        PMID： 8178433     DOI： 10.1006/viro.1994.1207

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  42 in total

1.  Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A1*02601 and Mamu-B*08301 reveals HLA-A2 and HLA-A3 supertypic specificities.

Authors:  Scott Southwood; Christopher Solomon; Ilka Hoof; Richard Rudersdorf; John Sidney; Bjoern Peters; Angela Wahl; Oriana Hawkins; William Hildebrand; Bianca R Mothé; Alessandro Sette
Journal:  Immunogenetics       Date:  2011-01-28       Impact factor: 2.846

2.  Shortening of the symptom-free period in rhesus macaques is associated with decreasing nonsynonymous variation in the env variable regions of simian immunodeficiency virus SIVsm during passage.

Authors:  P J Valli; V V Lukashov; J L Heeney; J Goudsmit
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

Review 3.  The Vpu protein: new concepts in virus release and CD4 down-modulation.

Authors:  Autumn Ruiz; John C Guatelli; Edward B Stephens
Journal:  Curr HIV Res       Date:  2010-04       Impact factor: 1.581

4.  Pathogenicity of simian-human immunodeficiency virus SHIV-89.6P and SIVmac is attenuated in cynomolgus macaques and associated with early T-lymphocyte responses.

Authors:  Keith A Reimann; Robert A Parker; Michael S Seaman; Kristin Beaudry; Margaret Beddall; Lauren Peterson; Kenneth C Williams; Ronald S Veazey; David C Montefiori; John R Mascola; Gary J Nabel; Norman L Letvin
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

5.  Simian-human immunodeficiency virus (SHIV) containing the nef/long terminal repeat region of the highly virulent SIVsmmPBj14 causes PBj-like activation of cultured resting peripheral blood mononuclear cells, but the chimera showed No increase in virulence.

Authors:  E B Stephens; S Mukherjee; Z Q Liu; D Sheffer; R Lamb-Wharton; K Leung; W Zhuge; S V Joag; Z Li; L Foresman; I Adany; O Narayan
Journal:  J Virol       Date:  1998-06       Impact factor: 5.103

6.  Chimeric simian/human immunodeficiency virus that causes progressive loss of CD4+ T cells and AIDS in pig-tailed macaques.

Authors:  S V Joag; Z Li; L Foresman; E B Stephens; L J Zhao; I Adany; D M Pinson; H M McClure; O Narayan
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

7.  Efficient mucosal transmissibility but limited pathogenicity of R5 SHIV SF162P3N in Chinese-origin rhesus macaques.

Authors:  Alexandra Mumbauer; Agegenhu Gettie; James Blanchard; Cecilia Cheng-Mayer
Journal:  J Acquir Immune Defic Syndr       Date:  2013-04-15       Impact factor: 3.731

8.  Modulation of the severe CD4+ T-cell loss caused by a pathogenic simian-human immunodeficiency virus by replacement of the subtype B vpu with the vpu from a subtype C HIV-1 clinical isolate.

Authors:  M Sarah Hill; Autumn Ruiz; Erik Pacyniak; David M Pinson; Nathan Culley; Bonnie Yen; Scott W Wong; Edward B Stephens
Journal:  Virology       Date:  2007-10-24       Impact factor: 3.616

9.  The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype.

Authors:  Christopher Solomon; Scott Southwood; Ilka Hoof; Richard Rudersdorf; Bjoern Peters; John Sidney; Clemencia Pinilla; Maria Cecilia Garibaldi Marcondes; Binhua Ling; Preston Marx; Alessandro Sette; Bianca R Mothé
Journal:  Immunogenetics       Date:  2010-05-18       Impact factor: 2.846

10.  The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-alpha/beta) and IFN-alpha/beta-inducible Mx in lymphoid tissues of rhesus macaques during acute and chronic infection.

Authors:  Kristina Abel; Michelle J Alegria-Hartman; Kristina Rothaeusler; Marta Marthas; Christopher J Miller
Journal:  J Virol       Date:  2002-08       Impact factor: 5.103
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