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Literature DB >> 8177249

Alterations in epithelial polarity and the pathogenesis of disease states.

Abstract

The establishment and maintenance of epithelial-cell polarity are prerequisites for normal epithelial-cell and organ function. Knowledge of the processes involved in cell polarity has provided insight into the mechanisms of cell dysfunction and the pathogenesis of several diseases. These insights should lead to the development of specific strategies aimed at preventing or minimizing the progression of these diseases.

Mesh：

Substances：
Membrane Proteins

Year: 1994 PMID： 8177249 DOI： 10.1056/NEJM199406023302207

Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245

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Cited

46 in total

1. Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway.

Authors: S H Hansen; M M Zegers; M Woodrow; P Rodriguez-Viciana; P Chardin; K E Mostov; M McMahon
Journal: Mol Cell Biol Date: 2000-12 Impact factor: 4.272

10. Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its trafficking.

Authors: G A Yudowski; R Efendiev; C H Pedemonte; A I Katz; P O Berggren; A M Bertorello
Journal: Proc Natl Acad Sci U S A Date: 2000-06-06 Impact factor: 11.205

Alterations in epithelial polarity and the pathogenesis of disease states.

1. Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway.

Review 2. Genesis and reversal of the ischemic phenotype in epithelial cells.

3. Intracellular redirection of plasma membrane trafficking after loss of epithelial cell polarity.

4. Label-free analysis of breast tissue polarity by Raman imaging of lipid phase.

5. Regulated synthesis and functions of laminin 5 in polarized madin-darby canine kidney epithelial cells.

6. Evolution of renal function and Na+, K +-ATPase expression during ischaemia-reperfusion injury in rat kidney.

7. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.

Review 8. Epithelial junctions and polarity: complexes and kinases.

Review 9. Regulation of the epithelial sodium channel by membrane trafficking.

10. Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its trafficking.