Literature DB >> 817679

Prevention of induced atherosclerosis by diversion of bile or blockade of intestinal lymphatics in dogs.

P J Wilk, R C Karipineni, D Pertsemlidis, C A Danese.   

Abstract

The prevention of induced hypercholesterolemia and atherosclerosis was studied by means of intestinal lymphatic blockade and of bile diversion in the dog. Hypercholesterolemia and atherosclerosis were produced by high cholesterol feeding after induction of hypothyroidism with radio-iodine plus thiouracil. Complete diversion of bile, by shunting all bile into the urinary bladder, effectively prevented hypercholesterolemia and atherosclerosis; in contrast, blockade of the intestinal lymphatics failed to prevent the consequences of the atherogenic regimen, because of the development of collateral lymphatic channels.

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Year:  1976        PMID： 817679      PMCID： PMC1344213          DOI： 10.1097/00000658-197604000-00014

Source DB:  PubMed          Journal:  Ann Surg        ISSN： 0003-4932            Impact factor:   12.969


  27 in total

1.  Micromethod for the direct determination of serum triglycerides.

Authors:  E VAN HANDEL; D B ZILVERSMIT
Journal:  J Lab Clin Med       Date:  1957-07

2.  Homozygous hypercholesteraemia and the portacaval shunt. The need for a concerted attack by surgeons and clinical researchers.

Authors:  E H Ahrens
Journal:  Lancet       Date:  1974-08-24       Impact factor: 79.321

3.  Portacaval shunt in hyperlipoproteinaemia.

Authors:  T E Starzl; C W Putnam; H P Chase; K A Porter
Journal:  Lancet       Date:  1973-10-27       Impact factor: 79.321

4.  The effect of bile diversion on induced hypercholesterolemia.

Authors:  H E Keig; R L Belmonte; J M McKain; J F Duesman; F A Miller
Journal:  Arch Surg       Date:  1968-04

5.  Cholestyramine therapy in patients homozygous for familial hypercholesterolemia (familial hypercholesterolemic xanthomatosis).

Authors:  A K Khachadurian
Journal:  J Atheroscler Res       Date:  1968 Jan-Feb

6.  An evaluation of bile diversion on induced hypercholesterolemia.

Authors:  P S McGreevy; M M Rowley; J F Duesman; D Houchin; F A Miller
Journal:  Arch Surg       Date:  1969-08

7.  [Arteriosclerosis obliterans of all four limbs. Hypercholesteremia and hyperlipemia. Ligation of the intestinal lymphatic trunk].

Authors:  J Monserrat; F Ballesta; L Torre
Journal:  Angiologia       Date:  1971 Mar-Apr

8.  The essential role of bile in the intestinal absorption of cholesterol.

Authors:  H Buchwald; R L Gebhard
Journal:  Surgery       Date:  1967-05       Impact factor: 3.982

9.  Prevention of experimental atherosclerosis by ileal bypass: 20 per cent cholesterol diet and I-131 induced hypothyroidism in dogs.

Authors:  H W Scott; S E Stephenson; R Younger; B B Carlisle; S W Turney
Journal:  Ann Surg       Date:  1966-05       Impact factor: 12.969

10.  Observations concerning the production and excretion of cholesterol in mammals. X. Factors affecting the absorption and fate of ingested cholesterol.

Authors:  M FRIEDMAN; S O BYERS; E SHIBATA
Journal:  J Exp Med       Date:  1953-08       Impact factor: 14.307
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